Three new dioxopiperazine metabolites from a marine-derived fungus Aspergillus fumigatus Fres.

被引：34
|
作者：
Zhao, Wen Ying [1 ,2 ]
Zhu, Tian Jiao [1 ]
Fan, Guo Tao [1 ]
Liu, Hong Bing [1 ]
Fang, Yu Chun [1 ]
Gu, Qian Qun [1 ]
Zhu, Wei Ming [1 ]
机构：
[1] Ocean Univ China, Inst Marine Drugs & Food, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China
[2] Qingdao Univ Sci & Technol, Qingdao 266042, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2010年 / 24卷 / 10期
关键词：
marine-derived fungus; Aspergillus fumigatus; dioxopiperazine metabolites; cytotoxicity; GLIOTOXIN;
D O I：
10.1080/14786410902726134
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Three new dioxopiperazine metabolites (1-3), together with two known compounds, N-acetyltyramine (4) and cyclo-(Ala-Val) (5), were isolated from a marine-derived fungus Aspergillus fumigatus Fres. Their structures were established by spectroscopic methods. Their cytotoxic activities against the K562 cell line were preliminarily evaluated by the sulphorhodamine B (SRB) method.
引用
收藏
页码：953 / 957
页数：5
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