A Divergent Strategy for Attaching Polypyridyl Ligands to Peptides

被引：17

作者：

Jabre, Nitinkumar D. ^{[1
]}

Respondek, Tomasz ^{[1
]}

Ulku, Selma A. ^{[1
]}

Korostelova, Nadiya ^{[1
]}

Kodanko, Jeremy J. ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 03期

关键词：

SOLID-PHASE SYNTHESIS; ALPHA-AMINO-ACIDS; DE-NOVO DESIGN; STEREOSELECTIVE-SYNTHESIS; METAL-COMPLEX; DNA CLEAVAGE; ENANTIOSELECTIVE SYNTHESIS; CELLULAR UPTAKE; IN-VITRO; DERIVATIVES;

D O I：

10.1021/jo9021953

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A divergent method for incorporating polypyridyl ligands into peptides is reported. Three N-Fmoc unnatural amino acids (1-3) that contain varying linkers between the alpha-carbon and a 2-(hydroxymethyl)pyridyl group were synthesized in enantioenriched form. These amino acids were used as anchors for incorporating multidentate ligands onto a peptide chain in a site-specific fashion. Multiple peptide-ligand conjugates were synthesized from single precursors by solution- or solid-phase methods. Peptides containing more than one metal-binding unit can be produced by this method.

引用

页码：650 / 659

页数：10

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