Readily available biaryl P,N ligands for asymmetric catalysis

被引：317
|
作者：
Knöpfel, TF [1 ]
Aschwanden, P [1 ]
Ichikawa, T [1 ]
Watanabe, T [1 ]
Carreira, EM [1 ]
机构：
[1] ETH Honggerberg, Organ Chem Lab, CH-8093 Zurich, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 44期
关键词：
asymmetric catalysis; atropisomerism; heterocycles; hydroboration; P; N ligands;
D O I：
10.1002/anie.200461286
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A short and modular synthesis of novel P,N ligands (pinap; see scheme; X = O or NH) is presented. A covalently bound chiral group allows the separation of the atropisomeric diastereomers, thus avoiding resolution involving chiral Pd-amine complexes. The utility of the ligands is demonstrated for three reactions catalyzed by different transition metals; in each case products are obtained with high enantiomeric excess (up to 99% ee).
引用
收藏
页码：5971 / 5973
页数：3
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