A new class of readily available and conformationally rigid phosphino-oxazoline ligands for asymmetric catalysis

被引：47
|
作者：
Liu, D [1 ]
Dai, Q [1 ]
Zhang, XM [1 ]
机构：
[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA
来源：
TETRAHEDRON | 2005年 / 61卷 / 26期
关键词：
ligand; catalysis; enantioselectivity;
D O I：
10.1016/j.tet.2005.03.111
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new class of conformationally rigid phosphino-oxazoline ligands 3 were synthesized via an efficient ortho-substitution of phenyl glycinol as the key step. Divergent synthetic routes for easy ligand modulation. as well as a procedure suitable for scale-up synthesis, were established. The catalytic potential of ligands 3 has been demonstrated in the highly enantioselective Ir-catalyzed hydrogenation of alkenes and Pd-catalyzed allylic substitution and intermolecular Heck reactions. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6460 / 6471
页数：12
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