Multifocal electroretinographic responses in sector retinitis pigmentosa

被引:3
|
作者
Giambene, Barbara [1 ]
Verdina, Tommaso [2 ]
Pennino, Monica [3 ]
Fabbrucci, Monica [3 ]
Cavallini, Gian Maria [2 ]
Menchini, Ugo [3 ]
机构
[1] Al Emadi Hosp, Doha, Qatar
[2] Univ Modena & Reggio Emilia, Inst Ophthalmol, Via Pozzo 71, I-41100 Modena, Italy
[3] Azienda Osped Univ Careggi, Ophthalmol Dept, Florence, Italy
关键词
Generalised retinitis pigmentosa; Multifocal electroretinography; Sector retinitis pigmentosa; RETINAL FUNCTION; RHODOPSIN; STANDARD; FIELD; ERG;
D O I
10.1007/s10792-019-01231-4
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Headings Multifocal electroretinography (mfERG) may be useful in the management of sector retinitis pigmentosa (SRP). Aim To compare multifocal electroretinographic responses in SRP, generalised retinitis pigmentosa (GRP), and healthy controls. Methods Eighteen patients with SRP, twelve with GRP, and fifteen controls were included in the study. All participants underwent: complete ophthalmological examination, Humphrey visual field testing, full-field ERG, and mfERG. The mean P1 amplitude, the implicit time (IT), and the mapping of the local responses were evaluated. Results The mean P1 amplitude was higher in the SRPs than in GRPs (p < 0.001), while it did not differ between SRPs and controls (p = 0.913). In the SRPs, the P1 amplitude in pathologic areas was higher than in the GRPs (p < 0.001). In normal areas, this parameter did not differ from the controls (p = 0.499). Moreover, in the SRPs, no differences in the P1 amplitude and the IT between pigmented and non-pigmented areas were found. Conclusion In the present study, the mfERG examination displayed significant differences between sector and generalised RP, showing normal values in sector RP even in pigmented areas. Considering the patients included in this study, SRP seems to represent a favourable variant of the disease, characterised by a limited retinal involvement and apparently mild functional damage. It is still unclear how these results can be extended to other forms of SRP.
引用
收藏
页码:703 / 708
页数:6
相关论文
共 50 条
  • [31] Relationship between multifocal ERG and VEP components in retinitis pigmentosa
    Paris, V
    Ziccardi, L
    Stifano, G
    Montrone, L
    Gallinaro, G
    Falsini, B
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 : U577 - U577
  • [32] Low-frequency damped electroretinographic wavelets in young asymptomatic patients with dominant retinitis pigmentosa - A new electroretinographic finding
    Lam, BL
    Liu, M
    Hamasaki, DI
    OPHTHALMOLOGY, 1999, 106 (06) : 1109 - 1113
  • [33] Sector Retinitis Pigmentosa caused by mutations of the RHO gene
    Li, Yang
    Xu, Ke
    Xiao, Ting
    Zhang, Xiaohui
    Xie, Yue
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2018, 59 (09)
  • [34] ELECTRORETINOGRAPHIC STUDIES IN XLPRA - A CANINE MODEL OF X-LINKED RETINITIS-PIGMENTOSA
    AGUIRRE, GD
    ACLAND, GM
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1994, 35 (04) : 1611 - 1611
  • [35] ELECTRORETINOGRAPHIC TESTING AS AN AID IN DETECTION OF CARRIERS OF X-CHROMOSOME-LINKED RETINITIS PIGMENTOSA
    BERSON, EL
    ROSEN, JB
    SIMONOFF, EA
    AMERICAN JOURNAL OF OPHTHALMOLOGY, 1979, 87 (04) : 460 - 468
  • [36] Autofluorescence and visual field loss in sector retinitis pigmentosa
    Meyerle, Catherine B.
    Fisher, Yale L.
    Spaide, Richard F.
    RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2006, 26 (02): : 248 - 250
  • [37] Genetic, Anatomical, and Functional Correlation of Sector Retinitis Pigmentosa
    Oliveira, Mariana A.
    Neves, Emmanuel
    Marques, Joao Pedro
    JAMA OPHTHALMOLOGY, 2020, 138 (06)
  • [38] Molecular insights into sector retinitis pigmentosa retinal disease
    Ramon, E.
    Toledo, D.
    Aguila, M.
    Moore, A. T.
    Webster, A. R.
    Cheetham, M. E.
    Garriga, P.
    FEBS JOURNAL, 2012, 279 : 429 - 430
  • [39] Sector Retinitis Pigmentosa caused by mutations of the RHO gene
    Xiao, Ting
    Xu, Ke
    Zhang, Xiaohui
    Xie, Yue
    Li, Yang
    EYE, 2019, 33 (04) : 592 - 599
  • [40] Sector Retinitis Pigmentosa caused by mutations of the RHO gene
    Ting Xiao
    Ke Xu
    Xiaohui Zhang
    Yue Xie
    Yang Li
    Eye, 2019, 33 : 592 - 599