Synthesis and preliminary in vitro evaluation of antimycobacterial activity of new pyrrolo[1,2-a]quinoxaline-carboxylic acid hydrazide derivatives

被引：38
|
作者：
Guillon, J
Reynolds, RC
Leger, JM
Guie, MA
Massip, S
Dallemagne, P
Jarry, C
机构：
[1] Univ Bordeaux 2, UFR Sci Pharmaceut, EA Pharmacochim 2962, F-33076 Bordeaux, France
[2] NIAID, TAACF, So Res Inst, Birmingham, AL 35255 USA
[3] Univ Caen, UFR Sci Pharmaceut, Ctr Etud & Rech Med Normandie, F-14032 Caen, France
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2004年 / 19卷 / 06期
关键词：
pyrrolo[1,2-a]quinoxaline-carboxylic acid hydrazide derivatives; Mycobacterium tuberculosis; antimycobacterial agents; tuberculosis;
D O I：
10.1080/14756360412331280464
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New pyrrolo[1,2-a]quinoxaline-2- or -4-carboxylic acid hydrazide derivatives were synthesized from nitroaniline or 1,2-phenylenediamine, and evaluated in vitro for their antimycobacterial activity as part of a TAACF TB screening program. Two compounds 7c and 13 showed an interesting activity at 6.25 mug/mL against Mycobacterium tuberculosis H(37)Rv, with a 94 and 100 percentage inhibition, respectively.
引用
收藏
页码：489 / 495
页数：7
相关论文
共 50 条
  • [21] Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives
    Carvalho, Samir A.
    da Silva, Edson F.
    de Souza, Marcus V. N.
    Lourenco, Maria C. S.
    Vicente, Felipe R.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (02) : 538 - 541
  • [22] Design, Synthesis and Anticancer Activity Evaluation of Some Novel Pyrrolo[1,2-a]azepine Derivatives
    Belal, Amany
    ARCHIV DER PHARMAZIE, 2014, 347 (07) : 515 - 522
  • [23] Research Process towards the Synthesis of Pyrrolo[1,2-a]quinoxaline Compounds
    Cong, Wenxia
    Wang, Li
    Yu, Fuqiang
    Li, Jixing
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 38 (11) : 2866 - 2878
  • [24] Synthesis and evaluation of the antiproliferative activity of novel isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives
    Desplat, Vanessa
    Moreau, Stephane
    Belisle-Fabre, Solene
    Thiolat, Denis
    Uranga, Juliette
    Lucas, Romain
    de Moor, Laure
    Massip, Stephane
    Jarry, Christian
    Mossalayi, Djavad M.
    Sonnet, Pascal
    Deleris, Gerard
    Guillon, Jean
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2011, 26 (05) : 657 - 667
  • [25] Synthesis of New Derivatives of Benzo[f]Pyrido[1,2-a]Indole Carboxylic Acid
    Len, Yulia
    Drapak, Iryna
    Kurka, Maria
    Zagorij, Glib
    Stasevych, Maryna
    Novikov, Volodymyr
    RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 2015, 6 (03): : 1749 - 1754
  • [26] NOVEL SYNTHESIS OF PYRROLO[1,2-A]PYRROLE DERIVATIVES
    KADUSHKIN, AV
    STEZKHO, TV
    GRANIK, VG
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1986, (04): : 564 - 565
  • [27] Synthesis of pyrrolo[1,2-a]quinoline spiro derivatives
    Glukhareva, TV
    D'yachenko, EV
    Morzherin, YY
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2002, (11): : 1610 - 1611
  • [28] Synthesis of Spiro Derivatives of Pyrrolo[1,2-a]quinoline
    T. V. Glukhareva
    E. V. D'yachenko
    Yu. Yu. Morzherin
    Chemistry of Heterocyclic Compounds, 2002, 38 (11) : 1426 - 1427
  • [29] A NEW SYNTHESIS OF PYRROLO(1,2-A)QUINOXALINES
    CHEESEMAN, GW
    TUCK, B
    CHEMISTRY & INDUSTRY, 1965, (31) : 1382 - +
  • [30] Design, synthesis, and biological evaluation of novel pyrrolo[1,2-a]pyrazine derivatives
    Kim, Jinwoo
    Park, Mikyung
    Choi, Jiwon
    Singh, Dileep Kumar
    Kwon, Ho Jeong
    Kim, Seong Hwan
    Kim, Ikyon
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 29 (11) : 1350 - 1356
12345