Synthesis and preliminary in vitro evaluation of antimycobacterial activity of new pyrrolo[1,2-a]quinoxaline-carboxylic acid hydrazide derivatives

被引：38
|
作者：
Guillon, J
Reynolds, RC
Leger, JM
Guie, MA
Massip, S
Dallemagne, P
Jarry, C
机构：
[1] Univ Bordeaux 2, UFR Sci Pharmaceut, EA Pharmacochim 2962, F-33076 Bordeaux, France
[2] NIAID, TAACF, So Res Inst, Birmingham, AL 35255 USA
[3] Univ Caen, UFR Sci Pharmaceut, Ctr Etud & Rech Med Normandie, F-14032 Caen, France
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2004年 / 19卷 / 06期
关键词：
pyrrolo[1,2-a]quinoxaline-carboxylic acid hydrazide derivatives; Mycobacterium tuberculosis; antimycobacterial agents; tuberculosis;
D O I：
10.1080/14756360412331280464
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New pyrrolo[1,2-a]quinoxaline-2- or -4-carboxylic acid hydrazide derivatives were synthesized from nitroaniline or 1,2-phenylenediamine, and evaluated in vitro for their antimycobacterial activity as part of a TAACF TB screening program. Two compounds 7c and 13 showed an interesting activity at 6.25 mug/mL against Mycobacterium tuberculosis H(37)Rv, with a 94 and 100 percentage inhibition, respectively.
引用
收藏
页码：489 / 495
页数：7
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