Indirect spectrophotometric determination of benzylpenicillin and cloxacillin in pharmaceutical preparations

被引：2
|
作者：
Helaleh, MIH [1 ]
机构：
[1] Aligarh Muslim Univ, Dept Chem, Anal Res Div, Aligarh 202002, Uttar Pradesh, India
来源：
MIKROCHIMICA ACTA | 1998年 / 129卷 / 1-2期
关键词：
benzylpenicillin; cloxacillin; spectrophotometry; pharmaceutical analysis;
D O I：
10.1007/BF01246845
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
An indirect spectrophotometric method for the determination of benzylpenicillin and cloxacillin is based on extraction of iodine produced by reduction of potassium iodate in acidic medium, where hydrolytic cleavage of a beta-lactam is achieved with sodium hydroxide. Beer's law is obeyed within the concentration ranges 0.04-0.8 mg ml(-1) benzylpenicillin and 0.02-0.5 mg ml(-1) cloxacillin. The precision, accuracy of the method and the effect of foreign substances were studied. The results have been statistically compared with those using the ammonium vanadate method. An oxidation mechanism is proposed.
引用
收藏
页码：29 / 32
页数：4
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