Structural revision of a Wnt/β-catenin modulator and confirmation of cannabielsoin constitution and configuration

被引：10
|
作者：
Monroe, Angelina Z. [1 ]
Gordon, William H. [1 ]
Wood, Jared S. [1 ]
Martin, Gary E. [2 ]
Morgan, Jeremy B. [1 ]
Williamson, R. Thomas [1 ]
机构：
[1] Univ N Carolina, Dept Chem & Biochem, Wilmington, NC 28409 USA
[2] Seton Hall Univ, Dept Chem, S Orange, NJ 07079 USA
来源：
CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 46期
基金：
美国国家科学基金会;
关键词：
3D STRUCTURE ELUCIDATION; RELATIVE CONFIGURATION; GUINEA-PIG; CANNABIDIOL; METABOLITE; CANNABINOIDS; COUPLINGS; CB1;
D O I：
10.1039/d1cc01971f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this report, we revise the structure for a previously reported synthetic product proposed to be the 1R,2S-cannabidiol epoxide and reassign it as cannabielsoin using anisotropic NMR and synthetic chemistry methods. These results provide a direct link to the first known biological target and function of cannabielsoin.
引用
收藏
页码：5658 / 5661
页数：4
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