Structural revision of a Wnt/β-catenin modulator and confirmation of cannabielsoin constitution and configuration

被引：10

作者：

Monroe, Angelina Z. ^{[1
]}

Gordon, William H. ^{[1
]}

Wood, Jared S. ^{[1
]}

Martin, Gary E. ^{[2
]}

Morgan, Jeremy B. ^{[1
]}

Williamson, R. Thomas ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem & Biochem, Wilmington, NC 28409 USA

[2] Seton Hall Univ, Dept Chem, S Orange, NJ 07079 USA

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 46期

基金：

美国国家科学基金会;

关键词：

3D STRUCTURE ELUCIDATION; RELATIVE CONFIGURATION; GUINEA-PIG; CANNABIDIOL; METABOLITE; CANNABINOIDS; COUPLINGS; CB1;

D O I：

10.1039/d1cc01971f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this report, we revise the structure for a previously reported synthetic product proposed to be the 1R,2S-cannabidiol epoxide and reassign it as cannabielsoin using anisotropic NMR and synthetic chemistry methods. These results provide a direct link to the first known biological target and function of cannabielsoin.

引用

页码：5658 / 5661

页数：4

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