Activities of isoniazid alone and in combination with other drugs against Mycobacterium avium infection in beige mice

被引：6
|
作者：
Fattorini, L [1 ]
Xiao, Y [1 ]
Mattei, M [1 ]
Li, YJ [1 ]
Iona, E [1 ]
Ricci, ML [1 ]
Thoresen, OF [1 ]
Creti, R [1 ]
Orefici, G [1 ]
机构：
[1] Ist Super Sanita, Lab Bacteriol & Med Mycol, I-00161 Rome, Italy
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 03期
关键词：
D O I：
10.1128/AAC.42.3.712
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Monotherapy with isoniazid or amikacin or clarithromycin or combinations of two of these drugs showed nil to modest therapeutic activity in beige mice infected with Mycobacterium avium. However, the combination of all three, isoniazid-amikacin-clarithromycin, markedly reduced CFUs in both spleens and lungs after 91 days of infection.
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页码：712 / 714
页数：3
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