The first solid-phase synthesis of a peptide-tethered platinum(II) complex

被引：0

作者：

Robillard, MS ^{[1
]}

Valentijn, ARPM ^{[1
]}

Meeuwenoord, NJ ^{[1
]}

van der Marel, GA ^{[1
]}

van Boom, JH ^{[1
]}

Reedijk, J ^{[1
]}

机构：

[1] Leiden Univ, Gorlaeus Labs, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2000年 / 39卷 / 17期

关键词：

D O I：

10.1002/1521-3773(20000901)39:17<3096::AID-ANIE3096>3.0.CO;2-D

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Assembly of an immobilized tripeptide, platination, and subsequent deprotection and release from the solid support are the key steps in the solid-phase peptide synthesis of the peptide-platinum(II) complex 1. This new methodology should be applicable for the preparation of a library of platinum antitumor compounds by a combinatorial synthesis approach.

引用

页码：3096 / 3099

页数：4

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