Synthesis of novel isoxazolo[2",3":1′,2′]pyrimido[4′,5′:4,5]pyrimido[6,1-b]quinazoline-8-ones and their in vitro anticancer and antimicrobial activities

被引：0
|
作者：
Rajanarendar, E. [1 ]
Kishore, B. [1 ]
Ramakrishna, S. [1 ]
Nagaraju, D. [1 ]
Venkateshwarlu, P. [1 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2014年 / 53卷 / 10期
关键词：
Isoxazolo[2 '',3 '':1 ',2 ']pyrimido[4 ',5 ':4,5]pyrimido[6,1-b]quinazoline-8-ones; one-pot synthesis; three-component reaction; anticancer activity; antimicrobial activity; INHIBITORS; DERIVATIVES; ANALOGS; DESIGN;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis of novel isoxazolo[2 '',3 '': 1',2']pyrimido[4',5':4,5]pyrimido[6,1-b]quinazoline-8-ones 6a-j, has been achieved by reaction of 5-amino-2-methyl-7-phenyl-7H-isoxazolo[2,3-a] pyrimidin-6-yl cyanides 4, with dimethyl formamide dimethylacetal followed by treatment with anthranilic acids in situ in one-pot. The key intermediate, viz., 5-amino-2-methyl-7-phenyl-7H-isoxazolo[2,3-a]pyrimidin-6-yl cyanide 4 is obtained by reaction of 3-amino-5-methyl isoxazole with aromatic aldehydes and malononitrile by a three-component one-pot process. The newly synthesized compounds 6a-j have been evaluated for their in vitro anticancer and antimicrobial activity. Compounds 6e and 6f exhibit potent anticancer and antimicrobial activity comparable to that of standard drugs.
引用
收藏
页码：1275 / 1283
页数：9
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