Photoredox-Catalyzed α-Aminoalkylcarboxylation of Allenes with CO2

被引：15
|
作者：
Hahm, Hyungwoo [1 ]
Baek, Doohyun [1 ]
Kim, Dowon [1 ]
Park, Seongwook [1 ]
Ryoo, Jeong Yup [1 ]
Hong, Sukwon [1 ,2 ]
机构：
[1] Gwangju Inst Sci & Technol, Dept Chem, Gwangju 61005, South Korea
[2] Gwangju Inst Sci & Technol, Sch Mat Sci & Engn, Gwangju 61005, South Korea
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
AMINOALKYL RADICALS; CARBOXYLATION; POTENTIALS; DRUG; GABA;
D O I：
10.1021/acs.orglett.1c01011
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The photoredox-catalyzed alpha-aminoalkylcarboxylation of aryl allenes with CO2 and N,N-dimethylanilines is reported for the first time (26 examples, up to 96% yield). In the case of electron-deficient allenes, good regioselectivity was observed (up to 94:6), exclusively generating kinetic products over thermodynamic products. This protocol is a novel synthetic method for highly functionalized beta,gamma-unsaturated gamma-aminobutyric esters.
引用
收藏
页码：3879 / 3884
页数：6
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