Voice Quality, Function, and Quality of Life for Laryngeal Cancer: A Prospective Longitudinal Study Up to 24 Months Following Radiotherapy

被引:9
|
作者
Tuomi, Lisa [1 ,2 ]
Karlsson, Therese [1 ,2 ]
机构
[1] Gothenburg Univ, Sahlgrenska Acad, Inst Clin Sci, Dept Otorhinolaryngol Head & Neck Surg, S-413 Gothenburg, Sweden
[2] Sahlgrens Univ Hosp, Reg Vastra Gotaland, Dept Otorhinolaryngol, Gothenburg, Sweden
关键词
larynx; radiology; quality of life; voice; dysphonia; EARLY GLOTTIC CANCER; NECK-CANCER; COMMUNICATION EXPERIENCES; RADIATION-THERAPY; SELF-EVALUATION; OUTCOMES; HEAD; QUESTIONNAIRE; CHEMORADIATION; CARCINOMA;
D O I
10.1177/0145561320929941
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Objective: To study the potential changes of health-related quality of life (HRQL), voice quality, and communicative function up to 24 months following radiotherapy for patients with laryngeal cancer. Methods: A total of 28 patients with laryngeal cancer, treated by curatively intended radiotherapy were included in this prospective longitudinal descriptive study. Patients were followed pre-radiotherapy, 12 months, and 24 months post-radiotherapy. At each time point, voice recordings and patient-reported outcome instruments (European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Core30, Head and Neck35, Swedish Self-Evaluation of Communication Experiences after Laryngeal Cancer) were completed. Perceptual analysis using the Grade-Roughness-Breathiness-Asthenia-Strain was performed using the voice recordings. Results: Voice quality remains inferior to the voices of healthy controls both before and up to 24 months post-radiotherapy, demonstrating no statistically significant changes during the study period. Self-perceived communicative function revealed a trend toward improvement. Health-related quality of life remains mostly at stable levels, however, with statistically significant deterioration regarding dry mouth and sticky saliva. Generally, patients reported inferior scores compared to a normal population. Conclusion: This study demonstrated no statistically significant changes over time in HRQL and perceptual voice quality at pre-radiotherapy compared to 24 months post-radiotherapy. However, the values remain inferior to the voices of healthy controls or a normal population.
引用
收藏
页码:913S / 920S
页数:8
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