Ifosfamide, gemcitabine, and vinorelbine is an effective salvage regimen with excellent stem cell mobilization in relapsed or refractory pediatric Hodgkin lymphoma

被引：5
|
作者：
Marr, Kristin [1 ]
Ronsley, Rebecca [1 ]
Nadel, Helen [2 ]
Douglas, Kate [1 ]
Gershony, Sharon [3 ]
Strahlendorf, Caron [1 ,4 ]
Davis, Jeffrey H. [1 ]
Deyell, Rebecca J. [1 ,4 ]
机构：
[1] Univ British Columbia, British Columbia Childrens Hosp, Div Pediat Hematol Oncol & Bone Marrow Transplant, Vancouver, BC, Canada
[2] Stanford Univ, Dept Radiol, Div Nucl Med, Stanford, CA 94305 USA
[3] Univ British Columbia, Dept Radiol, Div Nucl Med, Vancouver, BC, Canada
[4] Univ British Columbia, Child & Family Res Inst, Michael Cuccione Childhood Canc Res Program, Vancouver, BC, Canada
来源：
PEDIATRIC BLOOD & CANCER | 2020年 / 67卷 / 04期
关键词：
autologous stem cell transplantation; Hodgkin lymphoma; IGEV; pediatric; HIGH-DOSE THERAPY; CHILDREN; TRANSPLANTATION; DISEASE; ADOLESCENTS; CHEMOTHERAPY; RECURRENT;
D O I：
10.1002/pbc.28167
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We describe 12 pediatric patients (8-16 years) with primary refractory (N = 6) or first relapse (N = 6) Hodgkin lymphoma (HL) treated with ifosfamide, gemcitabine, and vinorelbine (IGEV). The overall response rate to IGEV was 100%, with seven (58%) complete responses (CR) and five (42%) partial responses. Successful CD34(+) stem cell mobilization was achieved in all patients. Following subsequent autologous stem cell transplantation, 10 patients (83%) achieved CR. At a median follow-up of 71 months, 11 patients had no evidence of disease. Five-year second event-free survival and overall survival were 83% +/- 11.0% and 90.0% +/- 9.5%, respectively. IGEV is an effective salvage regimen for children with relapsed/refractory HL.
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页数：5
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