Ifosfamide, gemcitabine, and vinorelbine is an effective salvage regimen with excellent stem cell mobilization in relapsed or refractory pediatric Hodgkin lymphoma

被引：5
|
作者：
Marr, Kristin [1 ]
Ronsley, Rebecca [1 ]
Nadel, Helen [2 ]
Douglas, Kate [1 ]
Gershony, Sharon [3 ]
Strahlendorf, Caron [1 ,4 ]
Davis, Jeffrey H. [1 ]
Deyell, Rebecca J. [1 ,4 ]
机构：
[1] Univ British Columbia, British Columbia Childrens Hosp, Div Pediat Hematol Oncol & Bone Marrow Transplant, Vancouver, BC, Canada
[2] Stanford Univ, Dept Radiol, Div Nucl Med, Stanford, CA 94305 USA
[3] Univ British Columbia, Dept Radiol, Div Nucl Med, Vancouver, BC, Canada
[4] Univ British Columbia, Child & Family Res Inst, Michael Cuccione Childhood Canc Res Program, Vancouver, BC, Canada
来源：
PEDIATRIC BLOOD & CANCER | 2020年 / 67卷 / 04期
关键词：
autologous stem cell transplantation; Hodgkin lymphoma; IGEV; pediatric; HIGH-DOSE THERAPY; CHILDREN; TRANSPLANTATION; DISEASE; ADOLESCENTS; CHEMOTHERAPY; RECURRENT;
D O I：
10.1002/pbc.28167
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We describe 12 pediatric patients (8-16 years) with primary refractory (N = 6) or first relapse (N = 6) Hodgkin lymphoma (HL) treated with ifosfamide, gemcitabine, and vinorelbine (IGEV). The overall response rate to IGEV was 100%, with seven (58%) complete responses (CR) and five (42%) partial responses. Successful CD34(+) stem cell mobilization was achieved in all patients. Following subsequent autologous stem cell transplantation, 10 patients (83%) achieved CR. At a median follow-up of 71 months, 11 patients had no evidence of disease. Five-year second event-free survival and overall survival were 83% +/- 11.0% and 90.0% +/- 9.5%, respectively. IGEV is an effective salvage regimen for children with relapsed/refractory HL.
引用
收藏
页数：5
相关论文
共 50 条
  • [1] IFOSFAMIDE, GEMCITABINE AND VINORELBINE (IGEV) IS AN EFFECTIVE SALVAGE REGIMEN WITH EXCELLENT STEM CELL MOBILIZATION IN RELAPSED AND REFRACTORY PEDIATRIC HODGKIN LYMPHOMA
    Marr, Kristin
    Nadel, Helen
    Strahlendorf, Caron
    Davis, Jeffrey
    Deyell, Rebecca
    PEDIATRIC BLOOD & CANCER, 2016, 63 : S15 - S15
  • [2] Gemcitabine and vinorelbine combination is effective in both as a salvage and mobilization regimen in relapsed or refractory Hodgkin lymphoma prior to ASCT
    Suyani, Elif
    Sucak, Gulsan Turkoz
    Aki, Sahika Zeynep
    Yegin, Zeynep Arzu
    Ozkurt, Zubeyde Nur
    Yagci, Munci
    ANNALS OF HEMATOLOGY, 2011, 90 (06) : 685 - 691
  • [3] Gemcitabine and vinorelbine combination is effective in both as a salvage and mobilization regimen in relapsed or refractory Hodgkin lymphoma prior to ASCT
    Elif Suyanı
    Gülsan Türköz Sucak
    Şahika Zeynep Akı
    Zeynep Arzu Yeğin
    Zübeyde Nur Özkurt
    Münci Yağcı
    Annals of Hematology, 2011, 90 : 685 - 691
  • [4] Ifosfamide, gemcitabine, and vinorelbine: a now induction regimen for refractory and relapsed Hodgkin's lymphoma
    Santoro, Armando
    Magagnoli, Massimo
    Spina, Michele
    Pinotti, Graziella
    Siracusano, Licia
    Michieli, Mariagrazia
    Nozza, Andrea
    Sarina, Barbara
    Morenghi, Emanuela
    Castagna, Luca
    Tirelli, Umberto
    Balzarotti, Monica
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 (01): : 35 - 41
  • [5] VINORELBINE, IFOSFAMIDE AND PREDNISOLONE AS A SALVAGE REGIMEN IN RELAPSED HODGKIN'S LYMPHOMA
    Abdel-Halim, I.
    El-ashry, M.
    El-sadda, W.
    ANNALS OF ONCOLOGY, 2010, 21 : 354 - 354
  • [6] Outcome and toxicity of ifosfamide, carboplatin, and etoposide versus gemcitabine and vinorelbine regimen for pediatric patients with relapsed or refractory Hodgkin's lymphoma
    Mahdy, Ahmed
    Hamoda, Asmaa
    Zaher, Ahmed
    Khorshed, Eman
    Elwakeel, Madeha
    Hassanein, Omneya
    Sidhom, Iman
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [7] Gemcitabine, vinorelbine and dexamethasone: A safe and effective regimen for treatment of relapsed/refractory hodgkin's lymphoma
    Ganesan, Prasanth
    Mehra, Nikita
    Joel, Anjana
    Radhakrishnan, Venkatraman
    Dhanushkodi, Manikandan
    Kalayarasi, Jayachandran Perumal
    Kannan, Krishnarathinam
    Ganesan, Trivadi S.
    Sagar, Tenali Gnana
    LEUKEMIA RESEARCH, 2019, 84
  • [8] Gemcitabine, dexamethasone, and cisplatin (GDP) as an effective therapy as salvage and mobilization regimen in patients with relapsed or refractory Hodgkin lymphoma.
    Gokmen, Ayla
    Soydan, Ender
    Gokgoz, Zafer
    Kurdal, Mevlude
    Tek, Ibrahim
    Ilhan, Osman
    Arslan, Onder
    Ozcan, Muhit
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [9] Gemcitabine, Cisplatin, and Dexamethasone as a Salvage and Mobilization Chemotherapy Before Autologous Stem Cell Transplantation is Effective and Safe Outpatient Regimen in Relapsed and Refractory Hodgkin Lymphoma Patients
    Gokmen, Ayla
    Sahin, Ugur
    Soydan, Ender
    Gokgoz, Zafer
    Okcu, Mevlude Kurdal
    Ozan, Ulku
    Arslan, Onder
    Ilhan, Osman
    Ozcan, Muhit
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 (10): : E885 - E892
  • [10] Gemcitabine, Vinorelbine and Dexamethasone (GVDexa) As Second-Line Salvage Regimen in Relapsed and Refractory Hodgkin's Lymphoma
    Joel, Anjana
    Ganesan, Prasanth
    Sagar, Tenali Gnana
    Kannan, Krishnarathnam
    Ganesan, Trivadi
    Radhakrishnan, Venkatraman
    Rajendranath, Rejiv
    Sundersingh, Shirley
    Vikas, Vandana
    BLOOD, 2015, 126 (23)
12345