Beyond Viral Interferon Regulatory Factors: Immune Evasion Strategies

被引：11

作者：

Myoung, Jinjong ^{[1
,2
]}

Lee, Shin-Ae ^{[3
]}

Lee, Hye-Ra ^{[4
]}

机构：

[1] Jeonbuk Natl Univ, Genet Engn Res Inst, Korea Zoonosis Res Inst, Jeonju 54531, South Korea

[2] Jeonbuk Natl Univ, Coll Nat Sci, Dept Bioact Mat Sci, Jeonju 54531, South Korea

[3] Univ Southern Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90007 USA

[4] Korea Univ, Dept Biotechnol & Bioinformat, Coll Sci & Technol, Sejong 30019, South Korea

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2019年 / 29卷 / 12期

关键词：

KSHV; viral interferon regulatory factor; immune evasion strategy; PRR-mediated signaling pathway; apoptosis pathway; KAPOSIS-SARCOMA; SIGNAL-TRANSDUCTION; INHIBITION; KSHV; TRANSCRIPTION; PATHWAY; PROTEIN; P53; IDENTIFICATION; ACTIVATION;

D O I：

10.4014/jmb.1910.10004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The innate immune response serves as a first-line-of-defense mechanism for a host against viral infection. Viruses must therefore subvert this anti-viral response in order to establish an efficient life cycle. In line with this fact, Kaposi's sarcoma-associated herpesvirus (KSHV) encodes numerous genes that function as immunomodulatory proteins to antagonize the host immune system. One such mechanism through which KSHV evades the host immunity is by encoding a viral homolog of cellular interferon (IFN) regulatory factors (IRFs), known as vIRFs. Herein, we summarize recent advances in the study of the immunomodulatory strategies of KSHV vIRFs and their effects on KSHV-associated pathogenesis.

引用

页码：1873 / 1881

页数：9

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