The Potential Applications of Hyaluronic Acid Hydrogels in Biomedicine

被引：78
|
作者：
Ahmadian, Elham [1 ,2 ,3 ]
Dizaj, Solmaz Maleki [1 ]
Eftekhari, Aziz [4 ]
Dalir, Elaheh [5 ]
Vahedi, Parviz [4 ]
Hasanzadeh, Amir [4 ]
Samiei, Mohammad [6 ]
机构：
[1] Tabriz Univ Med Sci, Dent & Periodontal Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Stem Cell & Regenerat Med Inst, Tabriz, Iran
[3] Tabriz Univ Med Sci, Students Res Comm, Tabriz, Iran
[4] Maragheh Univ Med Sci, Maragheh, Iran
[5] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Biomed Inst, Tabriz, Iran
[6] Tabriz Univ Med Sci, Fac Dent, Tabriz, Iran
来源：
DRUG RESEARCH | 2020年 / 70卷 / 01期
关键词：
regenerative medicine; drug delivery; biopharmaceuticals; STEM-CELL; TISSUE; ENCAPSULATION; RELEASE; CHONDROCYTES; FIBROBLASTS; MODEL;
D O I：
10.1055/a-0991-7585
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hyaluronic acid (HA) is widely used in the biomedicine due to its biocompatibility, biodegradability, and nontoxic properties. It is crucial for cell signaling role during morphogenesis, inflammation, and wound repair. After hydrogel formation, HA easily is converted to elastic sheets in order to use in preclinical and clinical applications. In addition, HA-derived hydrogels are easily used as vectors for cell and medication in tissue repairing and regenerative medicine. Moreover, in comparison with other polymers, HA -based hydrogels play a key role in in cellular behavior, including stem cell differentiation. The current paper reviews both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications.
引用
收藏
页码：6 / 11
页数：6
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