Electrochemical determination of paracetamol in presence of folic acid at nevirapine modified carbon paste electrode: A cyclic voltammetric study

被引：56
|
作者：
Tanuja, S. B. [1 ]
Swamy, B. E. Kumara [1 ]
Pai, K. Vasantakumar [1 ]
机构：
[1] Kuvempu Univ, Dept PG Studies & Res Ind Chem, Shimoga 577451, Karnataka, India
来源：
JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 2017年 / 798卷
关键词：
Paracetamol (PA); Folic acid (FA); Bare carbon paste electrode (BCPE); Nevirapine; Cyclic voltammetry; Differential pulse voltammetry (DPV); AMPEROMETRIC DETERMINATION; HIV-1; REPLICATION; ACETAMINOPHEN; SENSOR; INHIBITION; BEHAVIOR; PSEUDOEPHEDRINE; CHROMATOGRAPHY; DOPAMINE; REAGENT;
D O I：
10.1016/j.jelechem.2017.05.025
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The carbon paste electrode was modified by nevirapine drug, the voltammetric behaviour of paracetamol and folic acid at modified carbon paste electrode were investigated by cyclic voltammetric technique. The modified nevirapine carbon paste electrode showed an enhanced sensitivity towards paracetamol and folic acid. The modified nevirapine electrode had strong resolving capacity for overlapping voltammetric response of paracetamol and folic acid into two well resolved peaks, with increment of peak current as compared to the bare carbon paste electrode. The simultaneous determination of paracetamol in presence of folic acid without any interference is feasible at nevirapine modified carbon paste electrode, the detection limit of paracetamol and folic acid were found to be 0.77 mu M, 2.53 mu M respectively. The practical utility of the proposed electrode was evaluated by analysing paracetamol in pharmaceutical sample with satisfactory result.
引用
收藏
页码：17 / 23
页数：7
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