Authors' reply: the biologic importance of the vitamin D binding protein polymorphism in pediatric COVID-19 patients

被引：0

作者：

Bayramoglu, Elvan ^{[1
]}

Akkoc, Gulsen ^{[2
]}

Agbas, Ayse ^{[3
]}

Akgun, Ozlem ^{[4
]}

Yurdakul, Kamer ^{[5
]}

Duru, Hatice Nilgun Selcuk ^{[4
]}

Elevli, Murat ^{[4
]}

机构：

[1] Univ Hlth Sci, Haseki Training & Res Hosp, Dept Pediat Endocrinol, Istanbul, Turkey

[2] Univ Hlth Sci, Haseki Training & Res Hosp, Dept Pediat Infect Dis, Istanbul, Turkey

[3] Univ Hlth Sci, Haseki Training & Res Hosp, Dept Pediat Nephrol, Istanbul, Turkey

[4] Univ Hlth Sci, Haseki Training & Res Hosp, Dept Pediat, Istanbul, Turkey

[5] Univ Hlth Sci, Haseki Training & Res Hosp, Dept Biochem, Istanbul, Turkey

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2021年 / 180卷 / 08期

关键词：

COVID-19; Vitamin D; Vitamin D binding protein;

D O I：

10.1007/s00431-021-04109-9

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

What is Known?• Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection• Vitamin D binding protein (DBP) is the key transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolitesWhat is New?• Lower 25 OH vitamin D levels were associated with higher inflammation markers, suggesting an important role of vitamin D in the clinical course of COVID-19 in children and adolescents probably by regulating the systemic inflammatory response• Further studies are warranted to investigate the possible causal association of DBP levels and polymorphism with vitamin D status (total and bioavailable vitamin D) in COVID-19 patients

引用

页码：2709 / 2710

页数：2

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