Authors' reply: the biologic importance of the vitamin D binding protein polymorphism in pediatric COVID-19 patients

被引：0
|
作者：
Bayramoglu, Elvan [1 ]
Akkoc, Gulsen [2 ]
Agbas, Ayse [3 ]
Akgun, Ozlem [4 ]
Yurdakul, Kamer [5 ]
Duru, Hatice Nilgun Selcuk [4 ]
Elevli, Murat [4 ]
机构：
[1] Univ Hlth Sci, Haseki Training & Res Hosp, Dept Pediat Endocrinol, Istanbul, Turkey
[2] Univ Hlth Sci, Haseki Training & Res Hosp, Dept Pediat Infect Dis, Istanbul, Turkey
[3] Univ Hlth Sci, Haseki Training & Res Hosp, Dept Pediat Nephrol, Istanbul, Turkey
[4] Univ Hlth Sci, Haseki Training & Res Hosp, Dept Pediat, Istanbul, Turkey
[5] Univ Hlth Sci, Haseki Training & Res Hosp, Dept Biochem, Istanbul, Turkey
来源：
EUROPEAN JOURNAL OF PEDIATRICS | 2021年 / 180卷 / 08期
关键词：
COVID-19; Vitamin D; Vitamin D binding protein;
D O I：
10.1007/s00431-021-04109-9
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
What is Known?• Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection• Vitamin D binding protein (DBP) is the key transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolitesWhat is New?• Lower 25 OH vitamin D levels were associated with higher inflammation markers, suggesting an important role of vitamin D in the clinical course of COVID-19 in children and adolescents probably by regulating the systemic inflammatory response• Further studies are warranted to investigate the possible causal association of DBP levels and polymorphism with vitamin D status (total and bioavailable vitamin D) in COVID-19 patients
引用
收藏
页码：2709 / 2710
页数：2
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