Inflammatory mediators promote sickle red blood cell adhesion to endothelium under venular flow

被引：0
|
作者：
Owings, A [1 ]
Wagner, M [1 ]
Wick, T [1 ]
机构：
[1] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA
来源：
PROCEEDINGS OF THE 23RD EUROPEAN CONFERENCE ON MICROCIRCULATION | 2004年
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D O I：
暂无
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Adhesion of erythrocytes to microvascular endothelium is hypothesized as a key factor in the vaso-occlusive disorders of sickle cell anemia. Prevention of adhesion, which can be promoted by inflammatory cytokines such as TNF-alpha or histamine, may take the form of either blockade of adhesive receptors induced by stimulation or by control of the intracellular signaling cascade(s) that causes the expression of these receptors.
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页码：33 / 38
页数：6
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