Varenicline and mecamylamine attenuate locomotor sensitization and cross-sensitization induced by nicotine and morphine in mice

被引:22
|
作者
Biala, Grazyna [1 ]
Staniak, Natasza [1 ]
机构
[1] Med Univ Lublin, Dept Pharmacol & Pharmacodynam, PL-20081 Lublin, Poland
关键词
Nicotine; Morphine; Sensitization; Nicotinic receptors; Varenicline; Mecamylamine; Mice; RECEPTOR PARTIAL AGONIST; INDUCED ANTINOCICEPTION; DOPAMINE RELEASE; PLACE PREFERENCE; SMOKING; ALPHA-4-BETA-2; ANTAGONISTS; DEPENDENCE; BEHAVIOR; NUCLEUS;
D O I
10.1016/j.pbb.2010.04.022
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The present study focused on the evaluation of behavioural sensitization and cross-sensitization induced by nicotine and morphine in mice. First, we revealed that after 9 days of nicotine administration (0.175 mg/kg, free base), every other day and following its 7-day withdrawal, challenge doses of nicotine (0.175 mg/kg) and morphine (5 mg/kg) induced locomotor sensitization in mice. When we examined the influence of varenicline, a partial alpha4beta2 nicotinic receptor agonist (0.5, 1 and 2 mg/kg) and mecamylamine (0.5, 1 and 2 mg/kg), a non-selective nicotinic receptor antagonist, we found that both agents attenuated the acquisition and expression of nicotine sensitization as well as locomotor cross-sensitization between nicotine and morphine. Our results indicate similar cholinergic mechanisms involved in the locomotor stimulant effects of nicotine and morphine in mice, and as such these data may suggest that nicotinic neurotransmission could be a potential target for developing pharmacotherapeutic strategies to treat and prevent nicotine and/or opioid addiction. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:141 / 147
页数:7
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