A Perspective on Synthetic Biology in Drug Discovery and Development-Current Impact and Future Opportunities

被引：10

作者：

David, Florian ^{[1
]}

Davis, Andrew M. ^{[2
]}

Gossing, Michael ^{[3
]}

Hayes, Martin A. ^{[3
]}

Romero, Elvira ^{[3
]}

Scott, Louis H. ^{[3
]}

Wigglesworth, Mark J. ^{[4
]}

机构：

[1] Chalmers Univ Technol, Dept Biol & Biol Engn, Div Syst & Synthet Biol, Gothenburg, Sweden

[2] AstraZeneca, Biopharmaceut R&D, Discovery Sci, 310 Milton Rd, Cambridge CB4 0WG, England

[3] AstraZeneca, Biopharmaceut R&D, Discovery Sci, Gothenburg, Sweden

[4] AstraZeneca, Biopharmaceut R&D, Discovery Sci, Alderley Pk, Macclesfield, Cheshire, England

来源：

SLAS DISCOVERY | 2021年 / 26卷 / 05期

关键词：

biofoundry; chassis organism; CRISPR-Cas9; drug discovery; late-stage functionalization; synthetic biology; PROTEIN-PROTEIN INTERACTIONS; BIOSYNTHETIC GENE-CLUSTER; CYCLIC PEPTIDE INHIBITOR; DIRECTED EVOLUTION; SACCHAROMYCES-CEREVISIAE; NATURAL-PRODUCTS; SEMISYNTHETIC ARTEMISININ; ENGINEERING STRATEGIES; BINDING-PROTEIN; CELL FACTORIES;

D O I：

10.1177/24725552211000669

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The global impact of synthetic biology has been accelerating, because of the plummeting cost of DNA synthesis, advances in genetic engineering, growing understanding of genome organization, and explosion in data science. However, much of the discipline's application in the pharmaceutical industry remains enigmatic. In this review, we highlight recent examples of the impact of synthetic biology on target validation, assay development, hit finding, lead optimization, and chemical synthesis, through to the development of cellular therapeutics. We also highlight the availability of tools and technologies driving the discipline. Synthetic biology is certainly impacting all stages of drug discovery and development, and the recognition of the discipline's contribution can further enhance the opportunities for the drug discovery and development value chain.

引用

页码：581 / 603

页数：23

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