A Perspective on Synthetic Biology in Drug Discovery and Development-Current Impact and Future Opportunities

被引：10

作者：

David, Florian ^{[1
]}

Davis, Andrew M. ^{[2
]}

Gossing, Michael ^{[3
]}

Hayes, Martin A. ^{[3
]}

Romero, Elvira ^{[3
]}

Scott, Louis H. ^{[3
]}

Wigglesworth, Mark J. ^{[4
]}

机构：

[1] Chalmers Univ Technol, Dept Biol & Biol Engn, Div Syst & Synthet Biol, Gothenburg, Sweden

[2] AstraZeneca, Biopharmaceut R&D, Discovery Sci, 310 Milton Rd, Cambridge CB4 0WG, England

[3] AstraZeneca, Biopharmaceut R&D, Discovery Sci, Gothenburg, Sweden

[4] AstraZeneca, Biopharmaceut R&D, Discovery Sci, Alderley Pk, Macclesfield, Cheshire, England

来源：

SLAS DISCOVERY | 2021年 / 26卷 / 05期

关键词：

biofoundry; chassis organism; CRISPR-Cas9; drug discovery; late-stage functionalization; synthetic biology; PROTEIN-PROTEIN INTERACTIONS; BIOSYNTHETIC GENE-CLUSTER; CYCLIC PEPTIDE INHIBITOR; DIRECTED EVOLUTION; SACCHAROMYCES-CEREVISIAE; NATURAL-PRODUCTS; SEMISYNTHETIC ARTEMISININ; ENGINEERING STRATEGIES; BINDING-PROTEIN; CELL FACTORIES;

D O I：

10.1177/24725552211000669

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The global impact of synthetic biology has been accelerating, because of the plummeting cost of DNA synthesis, advances in genetic engineering, growing understanding of genome organization, and explosion in data science. However, much of the discipline's application in the pharmaceutical industry remains enigmatic. In this review, we highlight recent examples of the impact of synthetic biology on target validation, assay development, hit finding, lead optimization, and chemical synthesis, through to the development of cellular therapeutics. We also highlight the availability of tools and technologies driving the discipline. Synthetic biology is certainly impacting all stages of drug discovery and development, and the recognition of the discipline's contribution can further enhance the opportunities for the drug discovery and development value chain.

引用

页码：581 / 603

页数：23

共 50 条

[1] Global Drug Development-Current Trends, Challenges and Opportunities
Singh, Gurpreet
DRUG SAFETY, 2024, 47 (12) : 1322 - 1322
[2] The impact of synthetic biology on drug discovery
Weber, Wilfried
Fussenegger, Martin
DRUG DISCOVERY TODAY, 2009, 14 (19-20) : 956 - 963
[3] Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development-Current State-of-the-Art and Future Perspectives
Youhanna, Sonia
Kemas, Aurino M.
Preiss, Lena
Zhou, Yitian
Shen, Joanne X.
Cakal, Selgin D.
Paqualini, Francesco S.
Goparaju, Sravan K.
Shafagh, Reza Zandi
Lind, Johan Ulrik
Sellgren, Carl M.
Lauschke, Volker M.
PHARMACOLOGICAL REVIEWS, 2022, 74 (01) : 141 - 206
[4] Computational approaches in chemogenomics and chemical biology: current and future impact on drug discovery
Bajorath, Juergen
EXPERT OPINION ON DRUG DISCOVERY, 2008, 3 (12) : 1371 - 1376
[5] System biology and synthetic biology modify drug discovery and development
Haiech, Jacques
Ranjeva, Raoul
Kilhoffer, Marie-Claude
M S-MEDECINE SCIENCES, 2012, 28 (02): : 207 - 212
[6] Zika Vaccine Development-Current Progress and Challenges for the Future
Maslow, Joel N.
TROPICAL MEDICINE AND INFECTIOUS DISEASE, 2019, 4 (03)
[7] Antigens in lymphoma development-Current knowledge and future directions Introduction
Rosenquist, Richard
Davi, Frederic
Stamatopoulos, Kostas
SEMINARS IN CANCER BIOLOGY, 2013, 23 (06) : 397 - 398
[8] The impact of systems biology and biosimulation on drug discovery and development
Michelson, Seth
MOLECULAR BIOSYSTEMS, 2006, 2 (6-7) : 288 - 291
[9] Antihypertensive drug development: current challenges and future opportunities
Feig, Peter U.
Roy, Sophie
Cody, Robert J.
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, 2010, 4 (04) : 163 - 173
[10] Synthetic biology - reimagine drug discovery
Brooking, Stephanie
DRUG DISCOVERY TODAY, 2020, 25 (01) : 4 - 6

← 1 2 3 4 5 →