Pretreatment immunoscore and an inflamed tumor microenvironment (TME) are associated with efficacy in patients (Pts) with refractory large B cell lymphoma treated with axicabtagene ciloleucel (Axi-Cel) in ZUMA-1

被引:7
|
作者
Rossi, John M. [1 ]
Galon, Jerome [2 ]
Chang, Edmund [1 ]
Perbost, Regis [3 ]
Scholler, Nathalie [1 ]
Turcan, Sarah [3 ]
Danan, Corinne [3 ]
Locke, Frederick L. [4 ]
Neelapu, Sattva S. [5 ]
Miklos, David B. [6 ]
Jacobson, Caron A. [7 ]
Lekakis, Lazaros J. [8 ]
Lin, Yi [9 ]
Ghobadi, Armin [10 ]
Milletti, Francesca [1 ]
Go, William Y. [1 ]
Bot, Adrian [1 ]
机构
[1] Kite, Santa Monica, CA USA
[2] UPMC Univ Paris, Sorbonne Univ, Univ Paris Descartes, INSERM, Marseille, France
[3] HalioDx, Paris, France
[4] H Lee Moffitt Canc Ctr & Res Inst, Blood & Marrow Transplantat, Tampa, FL USA
[5] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, Houston, TX 77030 USA
[6] Stanford Univ, Sch Med, Blood & Marrow Transplantat, Stanford, CA 94305 USA
[7] Dana Farber Canc Inst, Boston, MA 02115 USA
[8] Univ Miami Hlth Syst, Sylvester Comprehens Canc Ctr, Miami, FL USA
[9] Mayo Clin, Div Hematol, Rochester, MN USA
[10] Washington Univ, Sch Med, Div Med Oncol, St Louis, MO USA
关键词
D O I
10.1158/1538-7445.AM2019-CT153
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
CT153
引用
收藏
页数:3
相关论文
共 50 条
  • [41] Prophylactic Corticosteroid Use with Axicabtagene Ciloleucel (Axi-Cel) in Patients (Pts) with Relapsed/ Refractory Large B-Cell Lymphoma (R/R LBCL): One-Year Follow-up of ZUMA-1 Cohort 6 (C6)
    Oluwole, Olalekan O.
    Forcade, Edouard
    Muñoz, Javier
    de Guibert, Sophie
    Vose, Julie M.
    Bartlett, Nancy L.
    Lin, Yi
    Deol, Abhinav
    McSweeney, Peter A.
    Goy, Andre H.
    Kersten, Marie Jose
    Jacobson, Caron
    Farooq, Umar
    Minnema, Monique C.
    Thieblemont, Catherine
    Timmerman, John M.
    Stiff, Patrick
    Avivi, Irit
    Tzachanis, Dimitrios
    Kim, Jenny J.
    Zheng, Yan
    Shen, Rhine R.
    Vardhanabhuti, Saran
    Van Meerten, Tom
    BLOOD, 2021, 138
  • [42] Pretreatment (PreTx) immune cell phenotypes in peripheral blood associated with the tumor immune contexture, product attributes, and durable clinical efficacy in patients with large B-cell lymphoma (LBCL) treated with axicabtagene ciloleucel (axi-cel).
    Budka, Justin
    Chou, Justin
    Plaks, Vicki
    Milletti, Francesca
    Wang, Zixing
    Locke, Frederick L.
    Neelapu, Sattva S.
    Miklos, David B.
    Jacobson, Caron A.
    Lekakis, Lazaros J.
    Lin, Yi
    Ghobadi, Armin
    Bashir, Zahid
    Scholler, Nathalie
    Galon, Jerome
    Rossi, John M.
    Bot, Adrian
    CANCER RESEARCH, 2021, 81 (13)
  • [43] Dynamic changes in the tumor microenvironment from initial diagnosis through sequential therapies in patients with large B cell lymphoma undergoing axicabtagene ciloleucel (axi-cel) treatment
    Mattie, Michael
    Perbost, Regis
    Auguste, Aurelie
    Turcan, Sarah
    Kim, Jenny J.
    To, Christina
    Nater, Jenny
    Filosto, Simone
    Shen, Rhine R.
    Galon, Jerome
    CANCER RESEARCH, 2024, 84 (07)
  • [44] The Phase 3, Randomized Study of Axicabtagene Ciloleucel (Axi-Cel) Versus Standard-of-Care Therapy in Patients With Relapsed/Refractory Diffuse Large B Cell Lymphoma: ZUMA-7
    Schmitz, N.
    Oluwole, O. O.
    Bishop, M. R.
    Gisselbrecht, C.
    Gordon, L. I.
    Kersten, M. J.
    Maloney, D. G.
    Caballero, M. D.
    Kuruvilla, J.
    Song, K. W.
    Jacobson, C. A.
    Nastoupil, L. J.
    Riedell, P.
    Jiang, Y.
    Rossi, J. M.
    Lee, L.
    Cheng, P.
    Locke, F. L.
    BRITISH JOURNAL OF HAEMATOLOGY, 2019, 185 : 90 - 91
  • [45] CLINICAL AND BIOLOGIC COVARIATES OF OUTCOMES IN ZUMA-1: A PIVOTAL TRIAL OF AXICABTAGENE CILOLEUCEL (AXI-CEL; KTE-C19) IN PATIENTS WITH REFRACTORY AGGRESSIVE NON-HODGKIN LYMPHOMA (NHL)
    Locke, F. L.
    Neelapu, S. S.
    Bartlett, N. L.
    Lekakis, L. J.
    Miklos, D.
    Jacobson, C. A.
    Braunschweig, I.
    Oluwole, O.
    Siddiqi, T.
    Lin, Y.
    Timmerman, J.
    Reagan, P. M.
    Bot, A.
    Rossi, J.
    Navale, L.
    Jiang, Y.
    Aycock, J.
    Elias, M.
    Wiezorek, J.
    Go, W. Y.
    HAEMATOLOGICA, 2017, 102 : 172 - 172
  • [46] Axicabtagene Ciloleucel (Axi-Cel) versus standard-of-care therapy in patients with relapsed/refractory diffuse large B cell lymphoma: The phase 3, randomized study, ZUMA-7
    Schmitz, N.
    Oluwole, O. O.
    Bishop, M. R.
    Gisselbrecht, C.
    Gordon, L. I.
    Kersten, M. J.
    Maloney, D. G.
    Caballero, M. D.
    Kuruvilla, J.
    Song, K. W.
    Jacobson, C. A.
    Nastoupil, L. J.
    Riedell, P.
    Jiang, Y.
    Rossi, J. M.
    Lee, L.
    Cheng, P.
    Locke, F. L.
    ONCOLOGY RESEARCH AND TREATMENT, 2018, 41 : 47 - 47
  • [47] Axicabtagene Ciloleucel (Axi-Cel) versus Standard-of-Care Therapy in Patients with Relapsed/Refractory Diffuse Large B Cell Lymphoma: ZUMA-7, A Phase 3, Randomized Study
    Oluwole, Olalekan O.
    Bishop, Michael R.
    Gisselbrecht, Christian
    Gordon, Leo I.
    Kersten, Marie Jose
    Maloney, David G.
    Schmitz, Norbert
    Dolores Caballero, Maria
    Kuruvilla, John
    Song, Kevin W.
    Jacobson, Caron A.
    Nastoupil, Loretta J.
    Riedell, Peter
    Jiang, Yizhou
    Rossi, John M.
    Lee, Lillian
    Cheng, Paul
    Locke, Frederick L.
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2018, 18 : S293 - S294
  • [49] Resource Utilization and Factors Prolonging Hospitalization for Patients with Refractory and Relapsed B-Cell Lymphoma Receiving Axicabtagene Ciloleucel (Axi-cel)
    Mian, Agrima
    Wei, Wei
    Hill, Brian T.
    Hamilton, Betty K.
    Pohlman, Brad
    Jagadeesh, Deepa
    Anwer, Faiz
    Kalaycio, Matt E.
    Dean, Robert M.
    Sobecks, Ronald M.
    Majhail, Navneet S.
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2020, 26 (03) : S44 - S45
  • [50] A Comparison of Two-Year Outcomes in ZUMA-1 (Axicabtagene Ciloleucel) and SCHOLAR-1 in Patients with Refractory Large B Cell Lymphoma
    Neelapu, Sattva S.
    Locke, Frederick L.
    Bartlett, Nancy L.
    Lekakis, Lazaros J.
    Reagan, Patrick M.
    Miklos, David B.
    Jacobson, Caron A.
    Braunschweig, Ira
    Oluwole, Olalekan O.
    Siddiqi, Tanya
    Lin, Yi
    Crump, Michael
    Kuruvilla, John
    Van den Neste, Eric
    Farooq, Umar
    Navale, Lynn
    DePuy, Venita
    Kim, Jenny J.
    Gisselbrecht, Christian
    BLOOD, 2019, 134