Anti-inflammatory isoflavonoids from the rhizomes of Iris germanica

被引:62
|
作者
Rahman, A
Nasim, S
Baig, I
Jalil, S
Orhan, I
Sener, B
Choudhary, MI [1 ]
机构
[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan
[2] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06572 Ankara, Turkey
关键词
Iris germanica L; Iridaceae; isoflavones; anti-inflammatory assay;
D O I
10.1016/S0378-8741(03)00055-2
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The anti-inflammatory activity of nine isoflavonoids 5,7-dihydroxy-3-(3'-hydroxy-4',5'dimethoxy)-8-methoxy-4H-1-benzopyran-4-one 1, 5,7-dihydroxy-3-(3'-hydroxyl-4', 5'-dimethoxy)-6-methoxy-4H-1-benzopyran-4-one 2, 5, 7-dihydroxy-3-(4'-hydroxy)-6-i-nethoxy-4H-1-benzopyrane-4-one 3, 5-hydroxy-3-(4'-hydroxy)-6,7-methylenedioxy-4H-1-benzopyran-4-one 4, 5-hydroxy-3-(4'-methoxy)-6,7-methylenedioxy-4H-1-benzopyran-4-one 5. 5-methoxy-3-(4'-hydroxy)-6,7-methyenedioxy-4H-1-benzopyran-4-one 6, 5,7-dihydroxy-3-(3-hydroxy-4'-methoxy l)-6-methoxy-4H-1-benzopyran-4-one 7, 5,7-dihydroxy-3-(3'-niethoxy-4'-hydroxy)-6-methoxy-4H-1-beiizopyran-4-one 8. and isopeonol 9 determined by a spectrophotometric assay using the activated human neurtrophilis. These isoflavonoids were isolated front an important folkloric medicinal plant Irsa (Iris germanica L.), a member of the family Iridaceae. Structures of these compounds were identified by spectral comparison with the reported data and active members of this group adds into the growing number of non-steroidal anti-inflammatory agents. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:177 / 180
页数:4
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