Carcinoembryonic antigen surge in metastatic colorectal cancer patients responding to irinotecan combination chemotherapy

被引：11
|
作者：
An, Xin [1 ,2 ]
Ding, Pei-Rong [1 ,3 ]
Xiang, Xiao-Juan [1 ,2 ]
Wang, Zhi-Qiang [1 ,2 ]
Wang, Feng-Hua [1 ,2 ]
Feng, Fen [1 ,2 ]
Jiang, Wen-Qi [1 ,2 ]
He, You-Jian [1 ,2 ]
Xu, Rui-Hua [1 ]
Li, Yu-Hong [1 ,2 ]
机构：
[1] State Key Lab Oncol S China, Guangzhou, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Ctr Canc, Dept Colorectal Surg, Guangzhou, Guangdong, Peoples R China
来源：
BIOMARKERS | 2010年 / 15卷 / 03期
关键词：
Carcinoembryonic antigen surge; chemotherapy; irinotecan; metastatic colorectal cancer; FOLINIC ACID; COLON-CANCER; TUMOR-MARKER; CEA; EXPRESSION; 5-FLUOROURACIL; OXALIPLATIN; THERAPY; CELLS; INCREASE;
D O I：
10.3109/13547500903477377
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Methods: We retrospectively reviewed 132 patients with metastatic colorectal cancer treated with irinotecan-based chemotherapy. Incidence of a CEA surge and chemotherapy efficacy were investigated. Results: Eleven of 99 eligible patients (11.1%) had CEA surges. None of the 11 patients showed progressive disease (four had a partial response, seven had stable disease). Conclusion: A CEA surge can be induced by irinotecan-based chemotherapy. An early increase in CEA after irinotecan-based chemotherapy does not usually indicate progression of disease and failure of therapy, and should not lead to a change of chemotherapy.
引用
收藏
页码：243 / 248
页数：6
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