Systematic Understanding of Anti-Aging Effect of Coenzyme Q10 on Oocyte Through a Network Pharmacology Approach

被引:18
|
作者
Yang, Liuqing [1 ]
Wang, Heng [1 ,2 ]
Song, SuJie [1 ,2 ]
Xu, Hongbin [3 ]
Chen, Yun [1 ]
Tian, Saisai [4 ]
Zhang, Yiqun [1 ]
Zhang, Qin [1 ]
机构
[1] Zhejiang Chinese Med Univ, Dept Tradit Chinese Med TCM Gynecol, Hangzhou Hosp Tradit Chinese Med, Hangzhou, Peoples R China
[2] Zhejiang Chinese Med Univ, Hangzhou, Peoples R China
[3] Guangzhou Univ Tradit Chinese Med, Clin Med Coll 2, Guangzhou, Peoples R China
[4] Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai, Peoples R China
来源
FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷
基金
中国国家自然科学基金;
关键词
oocyte; coenzyme Q10; molecular docking; mechanism; molecular dynamic simulation; aging; EXPRESSION; IVF; SUPPLEMENTATION; RECEPTOR; UPDATE; WOMEN;
D O I
10.3389/fendo.2022.813772
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundMaternal oocyte aging is strongly contributing to age-related decline in female fertility. Coenzyme Q10 (CoQ10) exerts positive effects in improving aging-related deterioration of oocyte quality, but the exact mechanism is unclear. ObjectiveTo reveal the system-level mechanism of CoQ10's anti-aging effect on oocytes based on network pharmacology. MethodsThis study adopted a systems network pharmacology approach, including target identification, data integration, network and module construction, bioinformatics analysis, molecular docking, and molecular dynamics simulation. ResultA total of 27 potential therapeutic targets were screened out. Seven hub targets (PPARA, CAT, MAPK14, SQSTM1, HMOX1, GRB2, and GSR) were identified. Functional and pathway enrichment analysis indicated that these 27 putative targets exerted therapeutic effects on oocyte aging by regulating signaling pathways (e.g., PPAR, TNF, apoptosis, necroptosisn, prolactin, and MAPK signaling pathway), and are involved oxidation-reduction process, mitochondrion, enzyme binding, reactive oxygen species metabolic process, ATP binding, among others. In addition, five densely linked functional modules revealed the potential mechanisms of CoQ10 in improving aging-related deterioration of oocyte quality are closely related to antioxidant, mitochondrial function enhancement, autophagy, anti-apoptosis, and immune and endocrine system regulation. The molecular docking study reveals that seven hub targets have a good binding affinity towards CoQ10, and molecular dynamics simulation confirms the stability of the interaction between the hub targets and the CoQ10 ligand. ConclusionThis network pharmacology study revealed the multiple mechanisms involved in the anti-aging effect of CoQ10 on oocytes. The molecular docking and molecular dynamics simulation provide evidence that CoQ10 may act on these hub targets to fight against oocytes aging.
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页数:13
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