Streptococcus pneumoniae serotype replacement in nasopharyngeal colonization in children vaccinated with PCV7, in Mexico

被引：5
|
作者：
Elena Espinosa-de los Monteros, Luz [1 ]
Aguilar-Ituarte, Felipe [2 ]
Norberto Jimenez-Juarez, Rodolfo [3 ]
Rodriguez-Suarez, Romeo S. [4 ]
Gomez-Barreto, Demostenes [1 ]
机构：
[1] Hosp Gen Manuel Gea Gonzalez, Mexico City 14080, DF, Mexico
[2] Hosp Infantil Mexico Fed Gomez, Mexico City, DF, Mexico
[3] Hosp Infectol, Cento Med Nacl La Raza, Inst Mexicano Seguro Social, Mexico City, DF, Mexico
[4] Secretaria Salud Mexico, Coordinac Asesores Secretaria Salud, Mexico City, DF, Mexico
来源：
SALUD PUBLICA DE MEXICO | 2010年 / 52卷 / 01期
关键词：
Streptococcus pneumoniae; nasopharinx; Mexico; PNEUMOCOCCAL CONJUGATE VACCINE; DAY-CARE-CENTERS; CARRIAGE; EMERGENCE; SERUM; IMMUNOGENICITY; ACQUISITION; ANTIBODIES; INFANTS; DISEASE;
D O I：
10.1590/S0036-36342010000100003
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objective.To assess the impact of pneumococcal conjugate vaccine (PCV7) immunization on pneumococcal nasopharyngeal colonization with S. pneumoniae (SPN). Material and Methods.We studied two groups with different vaccination schedules, group I (2-6 months of age) 3+1 and group II (7-11 months) 2+1, with a booster at 15 months. Nasopharyngeal cultures were obtained before administering each vaccination dose and after booster. Paired and global analyses were carried out of the proportions of children colonized by SPN, vaccine serotype, no vaccine serotype and resistance to penicillin. Results. A total of 183 children were enrolled; 93 in group I and 90 in group II. In group I, there was a decrease in vaccine serotypes in the third sample. In group II, there was an increase in non-vaccine serotypes and a decrease in vaccine serotypes before booster. Both groups showed a trend toward decreased resistance to penicillin. Conclusion. PCV7 caused serotype replacement in nasopharyngeal colonization before the booster.
引用
收藏
页码：4 / 13
页数：10
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