Caenorhabditis elegans as an alternative animal species

被引:29
|
作者
Williams, PL
Anderson, GL
Johnstone, JL
Nunn, AD
Tweedle, MF
Wedeking, P
机构
[1] Univ Georgia, Dept Environm Hlth Sci, Athens, GA 30602 USA
[2] Bracco Res, Princeton, NJ USA
来源
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES | 2000年 / 61卷 / 08期
基金
美国国家卫生研究院;
关键词
D O I
10.1080/00984100050195125
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Caenorhabditis elegans has proven useful in toxicity testing of known toxicants, but its potential for assessing the toxicity of new pharmaceuticals is relatively unexplored. In this study the procedures used in aquatic testing of toxicants were modified to permit testing of small amounts (<40 mg) of gadolinium-based magnetic resonance imaging ( MRI) compounds. Five blinded compounds were tested. The toxicity of these compounds determined using C. elegans was compared to existing mammalian test system data ( minimum lethal dose [MLD] values for mice). Four of five compounds tested had the same relative sensitivity with C. elegans as with the mouse test system. Testing with C. elegans is efficient and could markedly reduce the cost of screening potentially useful compounds.
引用
收藏
页码:641 / 647
页数:7
相关论文
共 50 条
  • [21] An alternative food source for metabolism and longevity studies in Caenorhabditis elegans
    Safa Beydoun
    Hyo Sub Choi
    Gabrielle Dela-Cruz
    Joseph Kruempel
    Shijiao Huang
    Daphne Bazopoulou
    Hillary A. Miller
    Megan L. Schaller
    Charles R. Evans
    Scott F. Leiser
    Communications Biology, 4
  • [22] An alternative food source for metabolism and longevity studies in Caenorhabditis elegans
    Beydoun, Safa
    Choi, Hyo Sub
    Dela-Cruz, Gabrielle
    Kruempel, Joseph
    Huang, Shijiao
    Bazopoulou, Daphne
    Miller, Hillary A.
    Schaller, Megan L.
    Evans, Charles R.
    Leiser, Scott F.
    COMMUNICATIONS BIOLOGY, 2021, 4 (01)
  • [23] Alternative splicing in the Caenorhabditis elegans DNA topoisomerase I gene
    Lee, MH
    Jang, YJ
    Koo, HS
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1998, 1396 (02): : 207 - 214
  • [24] Caenorhabditis elegans
    Blaxter, M
    Hope, I
    Barstead, R
    Kim, S
    YEAST, 2000, 17 (01) : 37 - 42
  • [25] Caenorhabditis elegans
    Labouesse, M
    M S-MEDECINE SCIENCES, 2003, 19 (12): : 1171 - 1172
  • [26] Using Caenorhabditis Elegans as a Model Animal for Assessing the Toxicity Induced by Tributyltin
    Wang, Yun
    Luo, Xun
    Yan, Shoubao
    Fan, Wei
    Chen, Qi
    2016 INTERNATIONAL CONFERENCE ON MATERIAL, ENERGY AND ENVIRONMENT ENGINEERING (ICM3E 2016), 2016, : 102 - 109
  • [27] THE EFFECT OF ETHANOL EXPOSURE ON LONGEVITY AND LOCOMOTION IN A CAENORHABDITIS ELEGANS ANIMAL MODEL
    Kormendi, Petra
    Hunn, Cynthia
    Hajdu, Gabor
    Soti, Csaba
    Barta, Csaba
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2019, 29 : S225 - S226
  • [28] Chemosensory Cue Conditioning With Stimulants in a Caenorhabditis Elegans Animal Model of Addiction
    Musselman, Heather N.
    Neal-Beliveau, Bethany
    Nass, Richard
    Engleman, Eric A.
    BEHAVIORAL NEUROSCIENCE, 2012, 126 (03) : 445 - 456
  • [29] A review of transgenerational and multigenerational toxicology in the in vivo model animal Caenorhabditis elegans
    Zhao, Yunli
    Chen, Jingya
    Wang, Rui
    Pu, Xiaoxiao
    Wang, Dayong
    JOURNAL OF APPLIED TOXICOLOGY, 2023, 43 (01) : 122 - 145
  • [30] Assessment of the effects of atmospheric pollutants using the animal model Caenorhabditis elegans
    Ficociello, Graziella
    Inverni, Agnese
    Massimi, Lorenzo
    Buccini, Giulio
    Canepari, Silvia
    Uccelletti, Daniela
    ENVIRONMENTAL RESEARCH, 2020, 191 (191)