Synthesis of Novel 4(3H)-Quinazolinones with 1,2,3-Triazoles Moiety Conjugated by Schiff Base

被引：9
|
作者：
Su, Changhui [1 ]
Liu, Xia [2 ]
机构：
[1] Nanjing Univ, Jinling Coll, Chem & Life Sci Coll, Nanjing 210089, Jiangsu, Peoples R China
[2] Jiangsu Open Univ, Dept Sci & Technol, Nanjing 210036, Jiangsu, Peoples R China
来源：
ASIAN JOURNAL OF CHEMISTRY | 2014年 / 26卷 / 16期
关键词：
Quinazolin-4(3H)-ones; Cytotoxic activity; Schiff base; 1,2,3-Triazoles; ANTIINFLAMMATORY ACTIVITY; AGENTS; AGONISTS; AZIDES;
D O I：
10.14233/ajchem.2014.17499
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe the synthesis of a novel quinazolin-4(3H)-ones i.e., (E)-3-[ 4-{4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl} benzylideneamino]-7-fluoro-2-methylquinazolin-4(3H)-one (7). Treatment of 4-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)benzaldehyde, which is synthesized via a click reaction of 4-azidobenzaldehyde and alkyne, with 3-amino-7-fluoro-2-methylquinazolin-4(3H)-one afforded the corresponding product in toluene catalyzed by TiCl4. in vitro Cytotoxic activity of compound 7 against human hepatoma hepg2 cells is evaluated.
引用
收藏
页码：5301 / 5304
页数：4
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