Preventive Activity of Ginger (Zingiber officinale) Against Myelotoxicity and Hepatotoxicity Induced by Cyclohexatriene and Identification of the Most Active Compounds by GC-MS

被引：0

作者：

Otmanine, K. ^{[1
]}

Hanini, S. ^{[2
]}

Benkortbi, O. ^{[2
]}

Bekri, R. ^{[3
]}

Amroun, K. ^{[4
]}

Djellal, M. ^{[5
]}

Kohli, S. ^{[1
]}

Oumouna-Benachour, K. ^{[5
]}

机构：

[1] Hassiba Benbouali Univ Chlef, Fac Technol, Bioressources Nat Locales LBRNI Lab, Dept Proc Engn, Chlef 02000, Algeria

[2] Yahia Fares Univ, Dept Chem Engn & Environm, Biomat & Transport Phenomena Lab LBMPTI, Medea 26000, Algeria

[3] Mohamed Boudiaf Hosp, Lab Haematol, Medea, Algeria

[4] Mohamed Boudiaf Hosp, Lab Pathol Anat, Medea, Algeria

[5] Yahia Fares Univ, Fac Sci, Dept Nat & Life Sci, Equipe Biol & Pharmacol Expt,Biomat & Transport P, Medea 26000, Algeria

来源：

KEMIJA U INDUSTRIJI-JOURNAL OF CHEMISTS AND CHEMICAL ENGINEERS | 2021年 / 70卷 / 7-8期

关键词：

Zingiber officinale; hepato-protective activity; cyclohexatriene; myelotoxicity; GC-MS; APOPTOSIS; LEUKEMIA;

D O I：

10.15255/KUI.2020.062

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study aimed to uncover the preventive capability of Zingiber officinale against myelotoxicity, leukaemia, and hepatotoxicity. For the most part, this work depended on the subcutaneous injection of cyclohexatriene in rabbits to cause the illness by a synthetic strategy. In parallel, another group of rabbits was exposed to the injection of cyclohexatriene under similar conditions with the feeding Zingiber officinale, where it was discovered that the cyclohexatriene-induced myelotoxicity was counteracted. The histological examination additionally uncovered the hepato-defensive intensity of Zingiber officinale. The most pharmacologically active molecules of Zingiber officinale were recognised by gas chromatography-mass spectrometry (GC-MS).

引用

页码：369 / 374

页数：6

共 46 条

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