Protecting groundwater is of growing interest as pressure on these resources grows. Recharge of groundwater takes place through the vadose zone, where complex interactions between thermal-hydrological-geochemicaI processes affect water quality. Monitoring processes in the vadose zone is an important means of evaluating the long-term health of aquifer systems. and has become an integral part of many subsurface engineering efforts. Monitoring such systems, however, may be affected by changes in climate that slowly propagate through vadose zone systems. We describe in this paper the use of NUFT-C, a reactive transport simulator designed to run on a high performance, massively parallel computer. to compare quantitatively the evolution of a deep vadose zone with changes expected from an engineered high-level nuclear waste repository. The results suggest that the impacts from waste emplacement are, in some instances, similar to those that would be observed as a result of climate change, whereas others are distinguishable from evolution of the natural system. Such simulations facilitate design of long-term monitoring programs that take account of these complex effect S. The results emphasize the importance of developing long-term baseline measurements and control sites, in order to enhance confidence in interpretations of complexly evolving data sets that will be obtained from multi-decade monitoring efforts. Published by Elsevier Science Ltd.