Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata

被引：37

作者：

Zhu, Feng ^{[1
,2
]}

Di, Ying-Tong ^{[1
]}

Liu, Ling-Li ^{[1
]}

Zhang, Qiang ^{[1
]}

Fang, Xin ^{[1
]}

Yang, Ting-Quan ^{[1
]}

Hao, Xiao-Jiang ^{[1
]}

He, Hong-Ping ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, Stale Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 02期

关键词：

ALKALOIDS;

D O I：

10.1021/np900309p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new neoclerodane diterpenoids, scutebatas A-G (1-7), have been isolated front Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their Structures Were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1. Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC50 value of 15.2 mu M.

引用

页码：233 / 236

页数：4

共 50 条

[41] NEOCLERODANE DITERPENOIDS FROM TEUCRIUM YEMENSE
SATTAR, EA
MOSSA, JS
MUHAMMAD, I
ELFERALY, FS
PHYTOCHEMISTRY, 1995, 40 (06) : 1737 - 1741
[42] Neoclerodane diterpenoids from Teucrium massiliense
Fontana, G
Paternostro, MP
Savona, G
Rodríguez, B
de la Torre, MC
JOURNAL OF NATURAL PRODUCTS, 1998, 61 (10): : 1242 - 1247
[43] Neoclerodane diterpenoids from Croton eluteria
Vigor, C
Fabre, N
Fouraste, I
Moulis, C
JOURNAL OF NATURAL PRODUCTS, 2002, 65 (08): : 1180 - 1182
[44] Neoclerodane diterpenoids from Ajuga taiwanensis
Chan, YY
CHEMICAL & PHARMACEUTICAL BULLETIN, 2005, 53 (02) : 164 - 167
[45] A new neoclerodane diterpenoid from Scutellaria hematochlora
Takeda, Y
Tateoka, S
Masuda, T
Otsuka, H
Honda, G
Takaishi, Y
Ito, M
Khodzhimatov, OK
Ashurmetov, OA
HETEROCYCLES, 2001, 55 (06) : 1141 - 1145
[46] New neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities
Dai, Sheng-Jun
Liang, Dong-Dong
Ren, Yan
Liu, Ke
Shen, Li
CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (02) : 207 - 209
[47] neo-Clerodane Diterpenoids from the Aerial Parts of Scutellaria barbata with Anti-Inflammatory Activity
Feng, Xue-Shan
Yan, Wei
Bai, Long-Hui
Wang, Kou
Chen, Xuan-Qin
CHEMISTRY & BIODIVERSITY, 2021, 18 (12)
[48] A neoclerodane diterpenoid from Scutellaria guatemalensis (Labiatae)
Esquivel, B
Dominguez, RM
Martinez, MA
EspinosaPerez, G
HETEROCYCLES, 1997, 45 (11) : 2247 - 2252
[49] New neo-clerodane diterpenoids from Scutellaria strigillosa with cytotoxic activities
Dai, Sheng-Jun
Xiao, Kai
Zhang, Lei
Han, Qing-Tong
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2016, 18 (05) : 456 - 461
[50] DITERPENOIDS FROM Scutellaria galericulata
Bozov, P. I.
Penchev, P. N.
Vasileva, T. A.
Iliev, I. N.
CHEMISTRY OF NATURAL COMPOUNDS, 2014, 50 (03) : 554 - 556

← 1 2 3 4 5 →