Promoting recovery from ischemic stroke

被引:28
|
作者
Schmidt, Antje [1 ]
Minnerup, Jens [1 ]
机构
[1] Univ Munster, Dept Neurol, Albert Schweitzer Campus 1,Gebaude A1, D-48149 Munster, Germany
关键词
Ischemic stroke; recovery; regeneration; neural plasticity; neurorestorative treatments; COLONY-STIMULATING FACTOR; INDUCED MOVEMENT THERAPY; MARROW MONONUCLEAR-CELLS; MIDDLE-CEREBRAL-ARTERY; BLOOD-BRAIN-BARRIER; RANDOMIZED EFFICACY TRIAL; ANIMAL-MODELS; FUNCTIONAL RECOVERY; ADULT-RAT; ENDOVASCULAR TREATMENT;
D O I
10.1586/14737175.2016.1134324
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Over recent decades, experimental and clinical stroke studies have identified a number of neurorestorative treatments that stimulate neural plasticity and promote functional recovery. In contrast to the acute stroke treatments thrombolysis and endovascular thrombectomy, neurorestorative treatments are still effective when initiated days after stroke onset, which makes them applicable to virtually all stroke patients. In this article, selected physical, pharmacological and cell-based neurorestorative therapies are discussed, with special emphasis on interventions that have already been transferred from the laboratory to the clinical setting. We explain molecular and structural processes that promote neural plasticity, discuss potential limitations of neurorestorative treatments, and offer a speculative viewpoint on how neurorestorative treatments will evolve.
引用
收藏
页码:173 / 186
页数:14
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