Sustained release of OIC-A006 from PLGA microspheres to induce osteogenesis of composite PLGA/β-TCP scaffolds

被引：2

作者：

Lin, Liulan ^{[1
]}

Dong, Yangyang ^{[1
]}

Zhou, Qi ^{[2
]}

机构：

[1] Shanghai Univ, Sch Mechatron Engn & Automat, Rapid Manufacture Engn Ctr, 99 Shangda Rd, Shanghai 200444, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, 197 Rui Jin 2nd Rd, Shanghai 200025, Peoples R China

来源：

SCIENCE AND ENGINEERING OF COMPOSITE MATERIALS | 2017年 / 24卷 / 05期

关键词：

bone repair materials; controlled drug release; drug-loaded microspheres; freeze-drying technology; OIC-A006; BONE REGENERATION; DELIVERY; BMP-2;

D O I：

10.1515/secm-2015-0372

中图分类号：

TB33 [复合材料];

学科分类号：

摘要：

In this article, poly(lactic-co-glycolic acid) (PLGA) microspheres containing the drug OIC-A006 were prepared by ice bath extraction and poly(lactic-co-glycolic acid)/beta-tricalcium phosphate (PLGA/beta-TCP) scaffolds were prepared by freeze-drying. Three kinds of scaffold were prepared by adding no drug, direct loading the drug, and loading with drug microspheres. The mechanical strength, degradation, and microstructure of the scaffolds were analyzed. The drug delivery properties of the scaffolds were determined using high-performance liquid chromatography (HPLC). It was found that PLGA/beta-TCP scaffolds with PLGA microspheres that contained the drug OIC-A006 exhibited a biphasic drug release pattern. Sustained release of the drug OIC-A006 was beneficial to cell adhesion and proliferation. Experiments on rats showed that composite PLGA/beta-TCP scaffolds with PLGA microspheres containing the drug OIC-A006 produced good bone formation and bone induction.

引用

页码：721 / 730

页数：10

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