Programming DNA replication origins and chromosome organization

被引：43
|
作者：
Cayrou, Christelle [1 ]
Coulombe, Philippe [1 ]
Mechali, Marcel [1 ]
机构：
[1] CNRS, Inst Human Genet, F-34980 Montpellier, France
来源：
CHROMOSOME RESEARCH | 2010年 / 18卷 / 01期
基金：
欧洲研究理事会;
关键词：
DNA replication origin; Chromatin; Nucleosome; DNA Loops; Transcription; Mitosis; Reprogramming; MATRIX ATTACHMENT REGIONS; HISTONE ACETYLTRANSFERASE HBO1; NUCLEAR-MATRIX; GENOME-WIDE; SCHIZOSACCHAROMYCES-POMBE; REPLICON CLUSTERS; INITIATION SITES; MAMMALIAN-CELLS; CHROMATIN LOOP; TRANSCRIPTION;
D O I：
10.1007/s10577-009-9105-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
During each cell cycle, thousands of DNA replication origins are activated in each cell of a metazoan organism. Although they appear site-specific, their usage and organization are rather plastic. Moreover, no strict sequence specificity has been observed in contrast to bacterial or Saccharomyces cerevisiae DNA replication origins. Epigenetic regulation linked to chromatin structure, chromosome organization, and transcription has been suggested to explain how DNA replication origins are selected and recognized by replication initiation factors. In this paper, we review these epigenetic features and discuss how, during the previous mitosis, chromosomal architecture might prepare DNA replication origins for a new cell cycle.
引用
收藏
页码：137 / 145
页数：9
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