Biotechnological applications of penicillin acylases:: state-of-the-art

被引：149
|
作者：
Arroyo, M [1 ]
de la Mata, I [1 ]
Acebal, C [1 ]
Castillón, MP [1 ]
机构：
[1] Univ Complutense Madrid, Dept Bioquim & Biol Mol 1, Fac Ciencias Biol, E-28040 Madrid, Spain
来源：
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2003年 / 60卷 / 05期
关键词：
D O I：
10.1007/s00253-002-1113-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This review describes the most recent developments in the biotechnological applications of penicillin acylases. This group of enzymes is involved mainly in the industrial production of 6-aminopenicillanic acid and the synthesis of semisynthetic beta-lactam antibiotics. In addition, penicillin acylases can also be employed in other useful biotrans formations, such as peptide synthesis and the resolution of racemic mixtures of chiral compounds. Particular emphasis is placed on advances in detection of new enzyme specificities towards other natural penicillins, enzyme immobilization, and optimization of enzyme-catalyzed hydrolysis and synthesis in the presence of organic solvents.
引用
收藏
页码：507 / 514
页数：8
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