Biotechnological applications of penicillin acylases:: state-of-the-art

被引：149
|
作者：
Arroyo, M [1 ]
de la Mata, I [1 ]
Acebal, C [1 ]
Castillón, MP [1 ]
机构：
[1] Univ Complutense Madrid, Dept Bioquim & Biol Mol 1, Fac Ciencias Biol, E-28040 Madrid, Spain
来源：
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2003年 / 60卷 / 05期
关键词：
D O I：
10.1007/s00253-002-1113-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This review describes the most recent developments in the biotechnological applications of penicillin acylases. This group of enzymes is involved mainly in the industrial production of 6-aminopenicillanic acid and the synthesis of semisynthetic beta-lactam antibiotics. In addition, penicillin acylases can also be employed in other useful biotrans formations, such as peptide synthesis and the resolution of racemic mixtures of chiral compounds. Particular emphasis is placed on advances in detection of new enzyme specificities towards other natural penicillins, enzyme immobilization, and optimization of enzyme-catalyzed hydrolysis and synthesis in the presence of organic solvents.
引用
收藏
页码：507 / 514
页数：8
相关论文
共 50 条
  • [1] Biotechnological applications of penicillin acylases: state-of-the-art
    M. Arroyo
    I. de la Mata
    C. Acebal
    M. Pilar Castillón
    Applied Microbiology and Biotechnology, 2003, 60 : 507 - 514
  • [2] Biotechnological applications of Candida antarctica lipase A:: State-of-the-art
    de María, PD
    Carboni-Oerlemans, C
    Tuin, B
    Bargeman, G
    van der Meer, A
    van Gemert, R
    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2005, 37 (1-6) : 36 - 46
  • [3] PENICILLIN ACYLASES - APPLICATIONS AND POTENTIALS
    SHEWALE, JG
    DESHPANDE, BS
    SUDHAKARAN, VK
    AMBEDKAR, SS
    PROCESS BIOCHEMISTRY, 1990, 25 (03) : 97 - 103
  • [4] Recent biotechnological interventions for developing improved penicillin G acylases
    Rajendhran, J
    Gunasekaran, P
    JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2004, 97 (01) : 1 - 13
  • [5] Biotechnological applications of bacteriophages: State of the art
    Harada, Liliam K.
    Silva, Erica C.
    Campos, Welida F.
    Del Fiol, Fernando S.
    Vila, Marta
    Dabrowska, Krystyna
    Krylov, Victor N.
    Balcao, Victor M.
    MICROBIOLOGICAL RESEARCH, 2018, 212 : 38 - 58
  • [6] PENICILLIN ACYLASES - AN UPDATE
    MAHAJAN, PB
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 1984, 9 (5-6) : 537 - 554
  • [7] State-of-the-art ciphers for commercial applications
    Preneel, Bart
    Computers and Security, 1999, 18 (01): : 67 - 74
  • [8] State-of-the-Art Duolingo Features and Applications
    Savvani, Stamatia
    CHALLENGES OF THE DIGITAL TRANSFORMATION IN EDUCATION, ICL2018, VOL 2, 2019, 917 : 139 - 148
  • [9] Biomedical Applications of Nanobiosensors: the State-of-the-Art
    Rai, Mahendra
    Gade, Aniket
    Gaikwad, Swapnil
    Marcato, Priscyla D.
    Duran, Nelson
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2012, 23 (01) : 14 - 24
  • [10] The State-of-the-Art of Terahertz Technologies and Applications
    Hu, Wei-dong
    Chen, Shi
    Li, Yade
    Zhu, Zhong-bo
    Liu, Yang
    Ligthart, Leo P.
    EURAD 2020 THE 17TH EUROPEAN RADAR CONFERENCE, 2021,
12345