Therapeutic Challenges in Neuroendocrine Tumors

被引：4
|
作者：
Legakis, Ioannis [1 ]
Saif, Muhammad Wasif [2 ]
Syrigos, Konstantinos [1 ]
机构：
[1] Athens Sch Med, Sotiria Gen Hosp, Dept Internal Med 3, Oncol Unit, Athens, Greece
[2] Tufts Univ, Dept Hematol Oncol, Med Ctr, Boston, MA 02111 USA
来源：
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2017年 / 17卷 / 07期
关键词：
Neuroendocrine tumors; biomarkers; somatostatin analogs; angiogenesis inhibitors; cytotoxic chemotherapy; radionuclide therapy; liver-targeted therapies; RECEPTOR RADIONUCLIDE THERAPY; PLASMA CHROMOGRANIN-A; ISLET-CELL TUMORS; LIVER-METASTASES; PHASE-II; GEP-NETS; SOMATOSTATIN ANALOGS; ENDOCRINE TUMORS; DIAGNOSIS; SURVIVAL;
D O I：
10.2174/1871520617666170213113401
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neuroendocrine tumors (NETs) are a diverse set of tumors, being genetically varied. NETs can be presented with a distinct clinical picture, due to the production of various hormones, or being silent. Based on community health clinical statistics, the frequency numbers and reported occurrence of NETs are increasing. Although the therapeutic options for NETs have expanded in recent years, clinical diagnosis is possible only when metastases are present, requiring chronic complicated medical management. A positive development is that the recent evolution of molecularly-targeted therapy in oncology promotes the evolution of innovative tools for the management of these tumors. A diverse assortment of medical specialists is needed to improve outcomes and orchestrate the therapeutic care plan for NET patients.
引用
收藏
页码：902 / 919
页数：18
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