Applying VHB acrylic elastomer as a cell culture and stretchable substrate

被引:10
|
作者
Khayamian, Mohammad Ali [1 ,2 ,3 ]
Ansaryan, Saeid [2 ,3 ]
Moghtaderi, Hassan [2 ,3 ,4 ]
Abdolahad, Mohammad [2 ,3 ]
机构
[1] Univ Tehran, Coll Engn, Sch Mech Engn, Tehran 111554563, Iran
[2] Univ Tehran, Nano Elect Ctr Excellence, Sch Elect & Comp Engn, Nano Bio Elect Devices Lab, POB 14395-515, Tehran, Iran
[3] Univ Tehran, Nano Elect Ctr Excellence, Sch Elect & Comp Engn, Thin Film & Nanoelect Lab, POB 14395-515, Tehran, Iran
[4] Univ Tehran, Coll Sci, Sch Biol, Dept Anim Biol, Tehran, Iran
关键词
Cell culture; elastomer; stretchable substrate; VHB; 4910; viability assays; MECHANICAL STIMULATION; MICROFLUIDIC CELL; GENE-EXPRESSION; CYCLIC STRAIN; CANCER-CELLS; ACTIN; MODULATION; PROLIFERATION; STRESS; POLYDIMETHYLSILOXANE;
D O I
10.1080/00914037.2017.1419244
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Elastomers are flexible polymers with low young's modulus and high failure strain. VHB, considered as an acrylic elastomer, is widely used in smart materials due to its dielectric and electromechanical actuating properties. To the best of our knowledge, this polymer has not been applied as cell culture and stretching substrate and this role has played by PDMS. Herein, we present the structural properties of VHB vs. PDMS and then prove the safety of using this polymer as cell culture substrate by different viability assays. Moreover, we analyzed the effect of stretching of VHB substrate on the cultured cells. [GRAPHICS] .
引用
收藏
页码:1096 / 1104
页数:9
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