Synthesis, structure, characterization and study of antiproliferative activity of dimeric and tetrameric oxidomolybdenum(VI) complexes of N,N′- disalicyloylhydrazine

被引：22

作者：

Pasayat, Sagarika ^{[1
]}

Dash, Subhashree P. ^{[1
]}

Majumder, Sudarshana ^{[1
]}

Dinda, Rupam ^{[1
]}

Sinn, Ekkehard ^{[2
]}

Stoeckli-Evans, Helen ^{[3
]}

Mukhopadhyay, Subhadip ^{[4
]}

Bhutia, Sujit K. ^{[4
]}

Mitra, Partha ^{[5
]}

机构：

[1] Natl Inst Technol, Dept Chem, Rourkela 769008, Odisha, India

[2] Western Michigan Univ, Dept Chem, Kalamazoo, MI 49008 USA

[3] Univ Neuchatel, Dept Chem, CH-2000 Neuchatel, Switzerland

[4] Natl Inst Technol, Dept Life Sci, Rourkela 769008, Odisha, India

[5] IACS Kolkata, Dept Inorgan Chem, Kolkata 700032, W Bengal, India

来源：

POLYHEDRON | 2014年 / 80卷

关键词：

N; '-Disalicyloylhydrazine; Oxidomolybdenum(VI); Dimeric and tetrameric complexes; X-ray crystal structure; Antiproliferative activity; ANTITUMOR-ACTIVITY; IN-VITRO; MOLYBDENUM(VI) COMPLEXES; IRON CHELATORS; DIOXOMOLYBDENUM(VI) COMPLEXES; HYDRAZONE DERIVATIVES; COPPER(II) COMPLEXES; INORGANIC-CHEMISTRY; CYTOTOXIC ACTIVITY; CRYSTAL-STRUCTURE;

D O I：

10.1016/j.poly.2014.04.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The in situ reaction of salicyloylhydrazide and its corresponding hydrazone with [MoO2(acac)(2)] afforded two novel and unusual dimeric [((MoO2)-O-VI)(2)L] (1) and tetrameric [{(C2H5OH)LO3Mo2VI}(2)(mu-O)(2)]center dot C2H5OH (2) oxidomolybdenum(VI) complexes with N,N'-disalicyloylhydrazine (H2L). The binucleating ligand was formed by the self-combination of the acid hydrazide or corresponding hydrazone. The complexes were characterized by various spectroscopic techniques (IR, UV and NMR) and also by electrochemical study. The molecular structures of both complexes have been confirmed by X-ray crystallography. The above studies indicate that the N,N'-disalicyloylhydrazine (H2L) has the normal tendency to form both dimeric and tetrameric complexes coordinated through the dianionic tridentate manner. The in vitro antiproliferative activity of complexes 1 and 2 was assayed against HeLa cell line. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：198 / 205

页数：8

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