A phase I/II trial of paclitaxel, carboplatin, and gemcitabine in untreated patients with advanced non-small cell lung cancer

被引：0
|
作者：
Kelly, K
Mikhaeel-Kamel, N
Pan, ZX
Murphy, J
Prindiville, S
Bunn, PA
机构：
[1] Univ Colorado, Hlth Sci Ctr, Ctr Canc, Div Med Oncol, Denver, CO 80262 USA
[2] Univ Colorado, Ctr Canc, Lung Canc Program, Denver, CO 80262 USA
[3] Univ Colorado, Ctr Canc, Dept Prevent Med & Biostat, Denver, CO 80262 USA
来源：
CLINICAL CANCER RESEARCH | 2000年 / 6卷 / 09期
关键词：
D O I：
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中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Paclitaxel and carboplatin is widely used in the treatment of patients with advanced non-small cell lung cancer (NSCLC); however, median survival remains <1 year. One strategy to improve survival is to add a third active drug with a differing mechanism of action. Gemcitabine is a novel antimetabolite with considerable activity in NSCLC. The primary objective of this Phase I/II study was to determine the maximally tolerated dose of gemcitabine administered with fixed doses of paclitaxel and carboplatin in untreated patients with advanced NSCLC.
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页码：3474 / 3479
页数：6
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