The CD1d natural killer T-cell antigen presentation pathway is highly conserved between humans and rhesus macaques

被引：19
|
作者：
Kashiwase, K
Kikuchi, A
Ando, Y
Nicol, A
Porcelli, SA
Tokunaga, K
Omine, M
Satake, M
Juji, T
Nieda, M [1 ]
Koezuka, Y
机构：
[1] MEDINET Co Ltd, Lab Mol Immunol, Tokyo, Japan
[2] Japanese Red Cross Tokyo Metropolitan Blood Ctr, Dept Lab, Tokyo, Japan
[3] Japanese Red Cross Cent Blood Ctr, Dept Res, Tokyo, Japan
[4] Univ Tokyo, Dept Human Genet, Grad Sch Med, Tokyo, Japan
[5] Univ Queensland, Dept Med, Queensland Inst Med Res, Brisbane, Qld 4000, Australia
[6] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA
[7] Showa Univ, Fujigaoka Hosp, Ctr Blood, Yokohama, Kanagawa 227, Japan
[8] Kirin Brewery Co Ltd, Pharmaceut Res Lab, Gunma, Japan
来源：
IMMUNOGENETICS | 2003年 / 54卷 / 11期
关键词：
alpha-GalCer; CD1d; V alpha 24NKT; rhesus macaque; nonhuman primate;
D O I：
10.1007/s00251-002-0527-8
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Natural killer T (NKT) cells play an important role in controlling cancers, infectious diseases and autoimmune diseases. Although the rhesus macaque is a useful primate model for many human diseases such as infectious and autoimmune diseases, little is known about their NKT cells. We analyzed Valpha24TCR+ T cells from rhesus macaque peripheral blood mononuclear cells stimulated with aalpha-galactosylceramide (a-GalCer) and interleukin-2. We found that rhesus macaques possess Va24TCR+ T cells, suggesting that recognition of alpha-GalCer is highly conserved between rhesus macaques and humans. The amino acid sequences of the V-J junction for the Valpha24TCR of rhesus macaque and human NKT cells are highly conserved (93% similarity), and the CD1d alpha1-alpha2 domains of both species are highly homologous (95.6%). These findings indicate that the rhesus macaque is a useful primate model for understanding the contribution of NKT cells to the control of human diseases.
引用
收藏
页码：776 / 781
页数：6
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