Objective: This study aimed to analyze the effect of different nursing models on the quality of life and swallowing function of stroke patients in China, and to provide relevant reference for rehabilitation nursing of stroke patients. Methods: This study was a clinical randomized controlled trial. The stroke patients from January 2017 to January 2019 were randomly divided into the experimental group and the control group. The experimental group was given comprehensive nursing, while the control group was given conventional nursing. The recovery of swallowing function, nerve function, cognitive function and quality of life were compared between the two groups. Results: A total of 3421 patients were examined, 55.31% of them were 60-70 years old, and 59% of them were female. Hypertension, diabetes, cardiac disease, hyperlipidemia and other diseases are still risk factors of stroke. After comprehensive nursing, the improvement of swallowing function in the experimental group was better than that in the control group (P < 0.05). The Chinese stroke scale (CSS) score of nerve function recovery in the experimental group was lower than that in the control group (P < 0.05). The recovery of limb function in the experimental group was better than that in the control group (P < 0.05). The Activities of daily living (ADL) score of life quality in the experimental group was better than that in the control group (P < 0.05). The moderate-to-severe depression rate in the experimental group was lower than that in the control group (P < 0.05). Conclusion: The results of this study indicate that female, age of 60-70 years old, and complicating hypertension, diabetes, cardiac disease, hyperlipidemia and other diseases are the risk factors of stroke. The application of comprehensive nursing during hospitalization is conducive to the recovery of swallowing function, the improvement of limb movement disorders, the nerve repair, the decreased incidence of post-stroke depression and the improvement of life quality.