Antinociceptive C19-Diterpenoid Alkaloids from Aconitum episcopale

被引：5
|
作者：
Hu, Jiang [1 ]
Li, Jiaxun [2 ]
Li, Qiang [1 ]
Mao, Xia [1 ]
Peng, Tianfeng [1 ]
Jin, Nianhua [1 ]
Yin, Si [1 ]
Shi, Xiaodong [1 ]
Li, Yu [3 ]
机构：
[1] Qujing Normal Univ, Coll Biol Resources & Food Engn, Qujing 655011, Peoples R China
[2] Kunming Med Univ, Affiliated Hosp 3, Tumor Hosp Yunnan Prov, Kunming 650118, Yunnan, Peoples R China
[3] Gen Hosp Northern Theater Command Chinese PLA, Dept Orthoped, Shenyang 110016, Liaoning, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2021年 / 57卷 / 03期
关键词：
Aconitum episcopale; Ranunculaceae; C-19-diterpenoid alkaloids; antinociceptive activity; DITERPENOID ALKALOIDS;
D O I：
10.1007/s10600-021-03397-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A chemical investigation of the 80% ethanol extract of the roots of Aconitum episcopale led to the isolation of two undescribed C-19-diterpenoid alkaloids, designated as episcopines A and B. The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated alkaloids were tested in vivo for antinociceptive potential. Episcopine A showed a 2-fold more potent antinociceptive effect (ID50 = 66.1 mu mol/kg) than the positive control drugs aspirin and acetaminophen.
引用
收藏
页码：503 / 506
页数：4
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