Ostruthin:: An antimycobacterial coumarin from the roots of Peucedanum ostruthium

被引：74
|
作者：
Schinkovitz, A
Gibbons, S
Stavri, M
Cocksedge, MJ
Bucar, F
机构：
[1] Graz Univ, Inst Pharmacognosy, A-8010 Graz, Austria
[2] Univ London, Ctr Pharmacognosy & Phytotherapy, Sch Pharm, London WC1E 7HU, England
[3] Univ London, Dept Pharmaceut & Biol Chem, Sch Pharm, London WC1E 7HU, England
来源：
PLANTA MEDICA | 2003年 / 69卷 / 04期
关键词：
D O I：
10.1055/s-2003-38876
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 muM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-en-yloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).
引用
收藏
页码：369 / 371
页数：3
相关论文
共 50 条
  • [21] bioNMR-based identification of natural anti-Aβ compounds in Peucedanum ostruthium
    Palmioli, Alessandro
    Bertuzzi, Sara
    De Luigi, Ada
    Colombo, Laura
    La Ferla, Barbara
    Salmona, Mario
    De Noni, Ivano
    Airoldi, Cristina
    BIOORGANIC CHEMISTRY, 2019, 83 : 76 - 86
  • [22] A new phenanthraquinone from the roots of Peucedanum praeruptorum
    Cun Zhang
    Chinese Chemical Letters, 2010, 21 (07) : 816 - 817
  • [23] Angular dihydropyranocoumarins from Peucedanum japonicum roots
    Hong, M. J.
    Kim, J.
    PLANTA MEDICA, 2014, 80 (10) : 780 - 780
  • [24] DIHYDROPYRANOCOUMARINS FROM ROOTS OF PEUCEDANUM-JAPONICUM
    IKESHIRO, Y
    MASE, I
    TOMITA, Y
    PHYTOCHEMISTRY, 1992, 31 (12) : 4303 - 4306
  • [25] A new phenanthraquinone from the roots of Peucedanum praeruptorum
    Zhang, Cun
    Li, Li
    Xiao, Yong Qing
    Li, Wen
    Yin, Xiao Jie
    Tian, Guo Fang
    Chen, Dong Dong
    Wang, Yun
    CHINESE CHEMICAL LETTERS, 2010, 21 (07) : 816 - 817
  • [26] NATURAL PRODUCT CHEMISTRY .51. 5-ALKOXY-FURANOCOUMARINS FROM PEUCEDANUM-OSTRUTHIUM
    REISCH, J
    KHALED, SA
    SZENDREI, K
    NOVAK, I
    PHYTOCHEMISTRY, 1975, 14 (08) : 1889 - 1890
  • [27] Germination responses of Peucedanum ostruthium (Apiaceae) to genotype, light, temperature and gibberellic acid
    Novak, J.
    Wawrosch, C.
    Schmiderer, C.
    Franz, C. M.
    Kopp, B.
    SEED SCIENCE AND TECHNOLOGY, 2011, 39 (03) : 552 - 558
  • [28] Essential oil from herb and rhizome of Peucedanum ostruthium (L. Koch.) ex DC.
    Cisowski, W
    Sawicka, U
    Mardarowicz, M
    Asztemborska, M
    Luczkiewicz, M
    ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES, 2001, 56 (11-12): : 930 - 932
  • [29] CYTOTOXIC PYRANOCOUMARINS FROM ROOTS OF PEUCEDANUM-JAPONICUM
    DUH, CY
    WANG, SK
    WU, YC
    PHYTOCHEMISTRY, 1992, 31 (05) : 1829 - 1830
  • [30] New Coumarins from Roots and Fruit of Peucedanum morisonii
    D. N. Olennikov
    Chemistry of Natural Compounds, 2022, 58 : 816 - 821
12345