Ostruthin:: An antimycobacterial coumarin from the roots of Peucedanum ostruthium

被引：74
|
作者：
Schinkovitz, A
Gibbons, S
Stavri, M
Cocksedge, MJ
Bucar, F
机构：
[1] Graz Univ, Inst Pharmacognosy, A-8010 Graz, Austria
[2] Univ London, Ctr Pharmacognosy & Phytotherapy, Sch Pharm, London WC1E 7HU, England
[3] Univ London, Dept Pharmaceut & Biol Chem, Sch Pharm, London WC1E 7HU, England
来源：
PLANTA MEDICA | 2003年 / 69卷 / 04期
关键词：
D O I：
10.1055/s-2003-38876
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 muM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-en-yloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).
引用
收藏
页码：369 / 371
页数：3
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